PMID- 19082447
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20131121
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 21
IP  - 1
DP  - 2009 Jan
TI  - A new therapeutic modality involving acridine orange excitation by photon energy 
      used during reduction surgery for rhabdomyosarcomas.
PG  - 89-94
AB  - Rhabdomyosarcoma is a common malignant soft tissue that frequently involves bone 
      and major neurovascular structures and resection of deep-seated rhabdomyosarcoma 
      can cause severe dysfunction in the affected limbs. Based on the mouse 
      osteosarcoma model, we developed a new surgical approach involving photodynamic 
      surgery (PDS), photodynamic therapy (PDT) and radiodynamic therapy (RDT) using 
      acridine orange (AO). Six rhabdomyosarcoma cases were treated using this new 
      modality after confirming the effectiveness of AO-PDT on human rhabdomyosarcoma 
      cell lines. All patients had almost normal limb function after surgery, with only 
      one recurrence. Based on these results, AO-PDS, PDT and RDT can be used to 
      preserve excellent limb function in patients with rhabdomyosarcoma involving 
      major nerves and vessels or bones.
FAU - Matsubara, Takao
AU  - Matsubara T
AD  - Department of Orthopaedic Surgery, Mie Postgraduate School of Medicine, Mie 
      Prefecture 514-8507, Japan.
FAU - Kusuzaki, Katsuyuki
AU  - Kusuzaki K
FAU - Matsumine, Akihiko
AU  - Matsumine A
FAU - Murata, Hiroaki
AU  - Murata H
FAU - Satonaka, Haruhiko
AU  - Satonaka H
FAU - Shintani, Ken
AU  - Shintani K
FAU - Nakamura, Tomoki
AU  - Nakamura T
FAU - Hosoi, Hajime
AU  - Hosoi H
FAU - Iehara, Tomoko
AU  - Iehara T
FAU - Sugimoto, Toru
AU  - Sugimoto T
FAU - Uchida, Atsumasa
AU  - Uchida A
LA  - eng
PT  - Case Reports
PT  - Clinical Trial
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*therapeutic use
MH  - Adolescent
MH  - Cell Line, Tumor
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Photochemotherapy/*methods
MH  - Photons/*therapeutic use
MH  - Rhabdomyosarcoma/pathology/*therapy
MH  - Soft Tissue Neoplasms/pathology/therapy
EDAT- 2008/12/17 09:00
MHDA- 2009/03/04 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
PST - ppublish
SO  - Oncol Rep. 2009 Jan;21(1):89-94.