PMID- 19082709 OWN - NLM STAT- MEDLINE DCOM- 20091117 LR - 20211020 IS - 1573-7217 (Electronic) IS - 0167-6806 (Print) IS - 0167-6806 (Linking) VI - 117 IP - 2 DP - 2009 Sep TI - No evidence that GATA3 rs570613 SNP modifies breast cancer risk. PG - 371-9 LID - 10.1007/s10549-008-0257-1 [doi] AB - GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. The rs570613 single nucleotide polymorphism (SNP) in intron 4 of GATA3 was previously found to be associated with a reduction in breast cancer risk in the Cancer Genetic Markers of Susceptibility project and in pooled analysis of two case-control studies from Norway and Poland (P (trend) = 0.004), with some evidence for a stronger association with estrogen receptor (ER) negative tumours [Garcia-Closas M et al. (2007) Cancer Epidemiol Biomarkers Prev 16:2269-2275]. We genotyped GATA3 rs570613 in 6,388 cases and 4,995 controls from the Breast Cancer Association Consortium (BCAC) and 5,617 BRCA1 and BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). We found no association between this SNP and breast cancer risk in BCAC cases overall (OR(per-allele) = 1.00, 95% CI 0.94-1.05), in ER negative BCAC cases (OR(per-allele) = 1.02, 95% CI 0.91-1.13), in BRCA1 mutation carriers RR(per-allele) = 0.99, 95% CI 0.90-1.09) or BRCA2 mutation carriers (RR(per-allele) = 0.93, 95% CI 0.80-1.07). We conclude that there is no evidence that either GATA3 rs570613, or any variant in strong linkage disequilibrium with it, is associated with breast cancer risk in women. FAU - Johnatty, Sharon E AU - Johnatty SE AD - Cancer and Cell Biology, Queensland Institute of Medical Research, c/o Royal Brisbane Hospital Post Office, Herston, Brisbane, QLD 4029, Australia. FAU - Couch, Fergus J AU - Couch FJ FAU - Fredericksen, Zachary AU - Fredericksen Z FAU - Tarrell, Robert AU - Tarrell R FAU - Spurdle, Amanda B AU - Spurdle AB FAU - Beesley, Jonathan AU - Beesley J FAU - Chen, Xiaoqing AU - Chen X CN - kConFab Investigators CN - AOCS Group CN - Swedish BRCA1 and BRCA2 Study Collaborators FAU - Gschwantler-Kaulich, Daphne AU - Gschwantler-Kaulich D FAU - Singer, Christian F AU - Singer CF FAU - Fuerhauser, Christine AU - Fuerhauser C FAU - Fink-Retter, Anneliese AU - Fink-Retter A FAU - Domchek, Susan M AU - Domchek SM FAU - Nathanson, Katherine L AU - Nathanson KL FAU - Pankratz, Vernon S AU - Pankratz VS FAU - Lindor, Noralane M AU - Lindor NM FAU - Godwin, Andrew K AU - Godwin AK FAU - Caligo, Maria A AU - Caligo MA FAU - Hopper, John AU - Hopper J FAU - Southey, Melissa C AU - Southey MC FAU - Giles, Graham G AU - Giles GG FAU - Justenhoven, Christina AU - Justenhoven C FAU - Brauch, Hiltrud AU - Brauch H FAU - Hamann, Ute AU - Hamann U FAU - Ko, Yon-Dschun AU - Ko YD FAU - Heikkinen, Tuomas AU - Heikkinen T FAU - Aaltonen, Kirsimari AU - Aaltonen K FAU - Aittomaki, Kristiina AU - Aittomaki K FAU - Blomqvist, Carl AU - Blomqvist C FAU - Nevanlinna, Heli AU - Nevanlinna H FAU - Hall, Per AU - Hall P FAU - Czene, Kamila AU - Czene K FAU - Liu, Jianjun AU - Liu J FAU - Peock, Susan AU - Peock S FAU - Cook, Margaret AU - Cook M FAU - Platte, Radka AU - Platte R FAU - Gareth Evans, D AU - Gareth Evans D FAU - Lalloo, Fiona AU - Lalloo F FAU - Eeles, Rosalind AU - Eeles R FAU - Pichert, Gabriella AU - Pichert G FAU - Eccles, Diana AU - Eccles D FAU - Davidson, Rosemarie AU - Davidson R FAU - Cole, Trevor AU - Cole T FAU - Cook, Jackie AU - Cook J FAU - Douglas, Fiona AU - Douglas F FAU - Chu, Carol AU - Chu C FAU - Hodgson, Shirley AU - Hodgson S FAU - Paterson, Joan AU - Paterson J FAU - Hogervorst, Frans B L AU - Hogervorst FB FAU - Rookus, Matti A AU - Rookus MA FAU - Seynaeve, Caroline AU - Seynaeve C FAU - Wijnen, Juul AU - Wijnen J FAU - Vreeswijk, Maaike AU - Vreeswijk M FAU - Ligtenberg, Marjolijn AU - Ligtenberg M FAU - van der Luijt, Rob B AU - van der Luijt RB FAU - van Os, Theo A M AU - van Os TA FAU - Gille, Hans J P AU - Gille HJ FAU - Blok, Marinus J AU - Blok MJ CN - HEBON FAU - Issacs, Claudine AU - Issacs C FAU - Humphreys, Manjeet K AU - Humphreys MK FAU - McGuffog, Lesley AU - McGuffog L FAU - Healey, Sue AU - Healey S FAU - Sinilnikova, Olga AU - Sinilnikova O FAU - Antoniou, Antonis C AU - Antoniou AC FAU - Easton, Douglas F AU - Easton DF FAU - Chenevix-Trench, Georgia AU - Chenevix-Trench G CN - Breast Cancer Association Consortium and Consortium of Investigators of Modifiers of BRCA1/2 LA - eng GR - U01 CA069417/CA/NCI NIH HHS/United States GR - CA128978/CA/NCI NIH HHS/United States GR - U01 CA69417/CA/NCI NIH HHS/United States GR - U01 CA069467/CA/NCI NIH HHS/United States GR - U01 CA069398/CA/NCI NIH HHS/United States GR - U01 CA69638/CA/NCI NIH HHS/United States GR - U01 CA069446/CA/NCI NIH HHS/United States GR - R01 CA102740/CA/NCI NIH HHS/United States GR - U01 CA069638/CA/NCI NIH HHS/United States GR - P50 CA83638/CA/NCI NIH HHS/United States GR - R01 CA122340-02/CA/NCI NIH HHS/United States GR - U01 CA069638-13/CA/NCI NIH HHS/United States GR - R01 CA128978-01A2/CA/NCI NIH HHS/United States GR - U01 CA069446-07/CA/NCI NIH HHS/United States GR - U01 CA069631-14/CA/NCI NIH HHS/United States GR - 11022/CRUK_/Cancer Research UK/United Kingdom GR - CA122340/CA/NCI NIH HHS/United States GR - R01 CA102740-01A2/CA/NCI NIH HHS/United States GR - U01 CA069398-15/CA/NCI NIH HHS/United States GR - R01 CA128978/CA/NCI NIH HHS/United States GR - UO1 CA69467/CA/NCI NIH HHS/United States GR - U01 CA069631/CA/NCI NIH HHS/United States GR - U01 CA69398/CA/NCI NIH HHS/United States GR - U01 CA69446/CA/NCI NIH HHS/United States GR - U01 CA69631/CA/NCI NIH HHS/United States GR - P50 CA083638/CA/NCI NIH HHS/United States GR - R01 CA122340/CA/NCI NIH HHS/United States GR - U01 CA069467-14/CA/NCI NIH HHS/United States GR - U01 CA069417-14/CA/NCI NIH HHS/United States GR - 10118/CRUK_/Cancer Research UK/United Kingdom GR - P50 CA083638-10/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20081211 PL - Netherlands TA - Breast Cancer Res Treat JT - Breast cancer research and treatment JID - 8111104 RN - 0 (GATA3 Transcription Factor) RN - 0 (GATA3 protein, human) SB - IM MH - Breast Neoplasms/*genetics MH - Female MH - GATA3 Transcription Factor/*genetics MH - Genes, BRCA1 MH - Genes, BRCA2 MH - *Genetic Predisposition to Disease MH - Genotype MH - Humans MH - Linkage Disequilibrium MH - Mutation MH - *Polymorphism, Single Nucleotide MH - Risk Factors PMC - PMC2728174 MID - NIHMS93105 FIR - Peock, Susan IR - Peock S FIR - Cook, Margaret IR - Cook M FIR - Haites, Neva IR - Haites N FIR - Gregory, Helen IR - Gregory H FIR - Morrison, Patrick IR - Morrison P FIR - Cole, Trevor IR - Cole T FIR - McKeown, Carole IR - McKeown C FIR - Burgess, Lucy IR - Burgess L FIR - Donaldson, Alan IR - Donaldson A FIR - Paterson, Joan IR - Paterson J FIR - Murray, Alexandra IR - Murray A FIR - Rogers, Mark IR - Rogers M FIR - McCann, Emma IR - McCann E FIR - Kennedy, John IR - Kennedy J FIR - Daly, Peter IR - Daly P FIR - Barton, David IR - Barton D FIR - Porteous, Mary IR - Porteous M FIR - Steel, Michael IR - Steel M FIR - Brewer, Carole IR - Brewer C FIR - Rankin, Julia IR - Rankin J FIR - Davidson, Rosemarie IR - Davidson R FIR - Murday, Victoria IR - Murday V FIR - Bradshaw, Nicola IR - Bradshaw N FIR - Watt, Catherine IR - Watt C FIR - Snadden, Lesley IR - Snadden L FIR - Longmuir, Mark IR - Longmuir M FIR - Izatt, Louise IR - Izatt L FIR - Pichert, Gabriella IR - Pichert G FIR - Langman, Caroline IR - Langman C FIR - Dorkins, Huw IR - Dorkins H FIR - Barwell, Julian IR - Barwell J FIR - Bishop, Timothy IR - Bishop T FIR - Chu, Carol IR - Chu C FIR - Ellis, Ian IR - Ellis I FIR - Evans, Gareth IR - Evans G FIR - Lalloo, Fiona IR - Lalloo F FIR - Shenton, Andrew IR - Shenton A FIR - Male, Alison IR - Male A FIR - Robinson, Anne IR - Robinson A FIR - Gardiner, Carol IR - Gardiner C FIR - Douglas, Fiona IR - Douglas F FIR - Burn, John IR - Burn J FIR - Side, Lucy IR - Side L FIR - Walker, Lisa IR - Walker L FIR - Durell, Sarah IR - Durell S FIR - Eeles, Ros IR - Eeles R FIR - Shanley, Susan IR - Shanley S FIR - Rahman, Naz IR - Rahman N FIR - Houlston, Richard IR - Houlston R FIR - Bancroft, Elizabeth IR - Bancroft E FIR - D'Mello, Lucia IR - D'Mello L FIR - Ardern-Jones, Audrey IR - Ardern-Jones A FIR - Cook, Jackie IR - Cook J FIR - Quarrell, Oliver IR - Quarrell O FIR - Hodgson, Shirley IR - Hodgson S FIR - Goff, Sheila IR - Goff S FIR - Eccles, Diana IR - Eccles D FIR - Lucassen, Anneke IR - Lucassen A FIR - Karlsson, Per IR - Karlsson P FIR - Nordling, Margareta IR - Nordling M FIR - Bergman, Annika IR - Bergman A FIR - Einbeigi, Zakaria IR - Einbeigi Z FIR - Stenmark-Askmalm, Marie IR - Stenmark-Askmalm M FIR - Liedgren, Sigrun IR - Liedgren S FIR - Borg, Ake IR - Borg A FIR - Loman, Niklas IR - Loman N FIR - Olsson, Hakan IR - Olsson H FIR - Kristoffersson, Ulf IR - Kristoffersson U FIR - Jernstrom, Helena IR - Jernstrom H FIR - Backenhorn, Katja IR - Backenhorn K FIR - Lindblom, Annika IR - Lindblom A FIR - Arver, Brita IR - Arver B FIR - von Wachenfeldt, Anna IR - von Wachenfeldt A FIR - Liljegren, Annelie IR - Liljegren A FIR - Barbany-Bustinza, Gisela IR - Barbany-Bustinza G FIR - Rantala, Johanna IR - Rantala J FIR - Gronberg, Henrik IR - Gronberg H FIR - Stattin, Eva-Lena IR - Stattin EL FIR - Emanuelsson, Monica IR - Emanuelsson M FIR - Bostrom, Hans IR - Bostrom H FIR - Rosenquist Brandell, Richard IR - Rosenquist Brandell R FIR - Dahl, Niklas IR - Dahl N FIR - Hogervorst, Frans IR - Hogervorst F FIR - Pijpe, Anouk IR - Pijpe A FIR - Verhoef, Senno IR - Verhoef S FIR - van Leeuwen, Flora IR - van Leeuwen F FIR - van 't Veer, Laura IR - van 't Veer L FIR - Rookus, Matti IR - Rookus M FIR - van den Ouweland, Ans IR - van den Ouweland A FIR - Schutte, Mieke IR - Schutte M FIR - Collee, Margriet IR - Collee M FIR - Jager, Agnes IR - Jager A FIR - Hooning, Maartje IR - Hooning M FIR - Seynaeve, Caroline IR - Seynaeve C FIR - Wijnen, Juul IR - Wijnen J FIR - van Asperen, Christi IR - van Asperen C FIR - Devilee, Peter IR - Devilee P FIR - Ligtenberg, Marjolijn IR - Ligtenberg M FIR - Hoogerbrugge, Nicoline IR - Hoogerbrugge N FIR - van der Luijt, Rob IR - van der Luijt R FIR - Ausems, Margreet IR - Ausems M FIR - Aalfs, Cora IR - Aalfs C FIR - van Os, Theo IR - van Os T FIR - Gille, Hans IR - Gille H FIR - Meijers-Heijboer, Hanne IR - Meijers-Heijboer H FIR - Blok, Rien IR - Blok R FIR - Gomez-Garcia, Encarna IR - Gomez-Garcia E EDAT- 2008/12/17 09:00 MHDA- 2009/11/18 06:00 PMCR- 2010/09/01 CRDT- 2008/12/17 09:00 PHST- 2008/11/12 00:00 [received] PHST- 2008/11/14 00:00 [accepted] PHST- 2008/12/17 09:00 [entrez] PHST- 2008/12/17 09:00 [pubmed] PHST- 2009/11/18 06:00 [medline] PHST- 2010/09/01 00:00 [pmc-release] AID - 10.1007/s10549-008-0257-1 [doi] PST - ppublish SO - Breast Cancer Res Treat. 2009 Sep;117(2):371-9. doi: 10.1007/s10549-008-0257-1. Epub 2008 Dec 11.