PMID- 19083105
OWN - NLM
STAT- MEDLINE
DCOM- 20090915
LR  - 20211020
IS  - 1573-7225 (Electronic)
IS  - 0957-5243 (Print)
IS  - 0957-5243 (Linking)
VI  - 20
IP  - 5
DP  - 2009 Jul
TI  - Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer 
      in smokers.
PG  - 681-90
LID - 10.1007/s10552-008-9281-z [doi]
AB  - OBJECTIVES: A history of type 2 diabetes is one of few consistent risk factors 
      for pancreatic cancer. Potentially modifiable factors related to fasting insulin 
      and glucose concentrations may influence pancreatic cancer risk. METHODS: 
      Multiple linear regression models were used to identify anthropometric, clinical, 
      behavioral, and dietary factors associated with fasting insulin and glucose in a 
      subcohort of non-diabetics in the Alpha-Tocopherol, Beta-Carotene Cancer 
      Prevention Study (n = 366). Hazards ratios (HRs) and 95% confidence intervals 
      (CIs) were calculated among the larger cohort (n = 27,035). RESULTS: During 
      follow-up (median 16.1 years), 305 participants developed pancreatic cancer. 
      Fasting insulin and/or glucose were positively associated with body mass index 
      (BMI), height, and dietary total and saturated fat and inversely associated with 
      serum high-density lipoprotein cholesterol (HDL) and dietary available 
      carbohydrates, sucrose, and alcohol. Comparing highest to lowest quintiles, total 
      fat (HR = 1.54, 95% CI 1.05-2.25, p-trend = 0.01) and saturated fat (HR = 1.38, 
      95% CI 0.97-1.98, p-trend = 0.06) were positively associated and available 
      carbohydrates (HR = 0.63, 95% CI 0.44-0.90, p-trend = 0.01), particularly sucrose 
      (HR = 0.62, 95% CI 0.43-0.89, p-trend = 0.09), were inversely associated with 
      risk of pancreatic cancer. BMI, HDL, height, and alcohol were not associated with 
      pancreatic cancer risk. CONCLUSION: Dietary fat is associated with higher fasting 
      insulin concentrations and may increase pancreatic cancer risk in smokers.
FAU - Meinhold, Cari L
AU  - Meinhold CL
AD  - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 
      NCI, 6120 Executive Blvd, Rockville, MD 20852, USA. meinholdc@mail.nih.gov
FAU - Berrington de Gonzalez, Amy
AU  - Berrington de Gonzalez A
FAU - Albanes, Demetrius
AU  - Albanes D
FAU - Weinstein, Stephanie J
AU  - Weinstein SJ
FAU - Taylor, Philip R
AU  - Taylor PR
FAU - Virtamo, Jarmo
AU  - Virtamo J
FAU - Stolzenberg-Solomon, Rachael Z
AU  - Stolzenberg-Solomon RZ
LA  - eng
GR  - N01 CN045165/CN/NCI NIH HHS/United States
GR  - N01RC37004/RC/CCR NIH HHS/United States
GR  - Z01 CP010195-01/ImNIH/Intramural NIH HHS/United States
GR  - N01-RC-45035/RC/CCR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20081213
PL  - Netherlands
TA  - Cancer Causes Control
JT  - Cancer causes & control : CCC
JID - 9100846
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Double-Blind Method
MH  - Humans
MH  - Insulin/*blood
MH  - Insulin Resistance
MH  - Linear Models
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*epidemiology
MH  - Smoking/*adverse effects
PMC - PMC2718707
MID - NIHMS85885
EDAT- 2008/12/17 09:00
MHDA- 2009/09/16 06:00
PMCR- 2010/07/01
CRDT- 2008/12/17 09:00
PHST- 2008/08/20 00:00 [received]
PHST- 2008/11/28 00:00 [accepted]
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/09/16 06:00 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - 10.1007/s10552-008-9281-z [doi]
PST - ppublish
SO  - Cancer Causes Control. 2009 Jul;20(5):681-90. doi: 10.1007/s10552-008-9281-z. 
      Epub 2008 Dec 13.