PMID- 19083400
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20220318
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 28
IP  - 3
DP  - 2008 Mar
TI  - Supplementation of hydrogen-rich water improves lipid and glucose metabolism in 
      patients with type 2 diabetes or impaired glucose tolerance.
PG  - 137-43
LID - 10.1016/j.nutres.2008.01.008 [doi]
AB  - Oxidative stress is recognized widely as being associated with various disorders 
      including diabetes, hypertension, and atherosclerosis. It is well established 
      that hydrogen has a reducing action. We therefore investigated the effects of 
      hydrogen-rich water intake on lipid and glucose metabolism in patients with 
      either type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We 
      performed a randomized, double-blind, placebo-controlled, crossover study in 30 
      patients with T2DM controlled by diet and exercise therapy and 6 patients with 
      IGT. The patients consumed either 900 mL/d of hydrogen-rich pure water or 900 mL 
      of placebo pure water for 8 weeks, with a 12-week washout period. Several 
      biomarkers of oxidative stress, insulin resistance, and glucose metabolism, 
      assessed by an oral glucose tolerance test, were evaluated at baseline and at 8 
      weeks. Intake of hydrogen-rich water was associated with significant decreases in 
      the levels of modified low-density lipoprotein (LDL) cholesterol (ie, 
      modifications that increase the net negative charge of LDL), small dense LDL, and 
      urinary 8-isoprostanes by 15.5% (P < .01), 5.7% (P < .05), and 6.6% (P < .05), 
      respectively. Hydrogen-rich water intake was also associated with a trend of 
      decreased serum concentrations of oxidized LDL and free fatty acids, and 
      increased plasma levels of adiponectin and extracellular-superoxide dismutase. In 
      4 of 6 patients with IGT, intake of hydrogen-rich water normalized the oral 
      glucose tolerance test. In conclusion, these results suggest that supplementation 
      with hydrogen-rich water may have a beneficial role in prevention of T2DM and 
      insulin resistance.
FAU - Kajiyama, Sizuo
AU  - Kajiyama S
AD  - Kajiyama Clinic, Kyoto 615-0035, Japan.
FAU - Hasegawa, Goji
AU  - Hasegawa G
FAU - Asano, Mai
AU  - Asano M
FAU - Hosoda, Hiroko
AU  - Hosoda H
FAU - Fukui, Michiaki
AU  - Fukui M
FAU - Nakamura, Naoto
AU  - Nakamura N
FAU - Kitawaki, Jo
AU  - Kitawaki J
FAU - Imai, Saeko
AU  - Imai S
FAU - Nakano, Koji
AU  - Nakano K
FAU - Ohta, Mitsuhiro
AU  - Ohta M
FAU - Adachi, Tetsuo
AU  - Adachi T
FAU - Obayashi, Hiroshi
AU  - Obayashi H
FAU - Yoshikawa, Toshikazu
AU  - Yoshikawa T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 059QF0KO0R (Water)
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Glucose/*drug effects/metabolism
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/blood/drug therapy/*metabolism
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Glucose Intolerance
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hydrogen/metabolism/*pharmacology
MH  - Lipid Metabolism/*drug effects/physiology
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*drug effects
MH  - Treatment Outcome
MH  - Water/*pharmacology
EDAT- 2008/12/17 09:00
MHDA- 2009/03/07 09:00
CRDT- 2008/12/17 09:00
PHST- 2007/09/05 00:00 [received]
PHST- 2007/12/26 00:00 [revised]
PHST- 2008/01/17 00:00 [accepted]
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
AID - S0271-5317(08)00023-7 [pii]
AID - 10.1016/j.nutres.2008.01.008 [doi]
PST - ppublish
SO  - Nutr Res. 2008 Mar;28(3):137-43. doi: 10.1016/j.nutres.2008.01.008.