PMID- 19083444
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20081216
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 28
IP  - 7
DP  - 2008 Jul
TI  - Short-term changes in lipoprotein subclasses and C-reactive protein levels of 
      hypertriglyceridemic adults on low-carbohydrate and low-fat diets.
PG  - 443-9
LID - 10.1016/j.nutres.2008.03.013 [doi]
AB  - Diets designed to promote weight loss and improve atherogenic lipid profiles 
      traditionally include a reduction in total fat and, in particular, saturated 
      fats. This study was designed to test the efficacy of a low-fat diet vs a 
      carbohydrate (CHO)-restricted (low-CHO) diet in hypertriglyceridemic patients on 
      lipid profile, weight loss, high-sensitivity C-reactive protein (hs-CRP), and 
      satiety. Twenty-eight hypertriglyceridemic subjects (based on fasting 
      triacylglycerol [TG] levels exceeding 1.69 mmol/L) were randomized to either the 
      low-CHO or low-fat diet for 8 weeks. Fasting bloods were acquired at weeks 0 and 
      8 and analyzed for lipids and hs-CRP. Body weight and other anthropometric 
      measures were also obtained. Three random 24-hour food recalls were used to 
      assess compliance during the trial and 2 recalls before randomization to permit 
      individualized dietary education. A significant time-by-treatment interaction was 
      observed (P = .045), wherein the small low-density lipoprotein cholesterol 
      concentrations were reduced by 46% in the low-CHO-assigned subjects and increased 
      by 36% for those assigned the low-fat plan. The observed decrease in TG (18%) 
      among low-CHO subjects, in contrast to the 4% increase for low-fat group, was not 
      significant, nor were there significant differences in hs-CRP, overall dietary 
      compliance, satiety, or the magnitude of body weight loss between groups (low-CHO 
      group, -3.8% vs low-fat group, -1.6%). Favorable reductions in small low-density 
      lipoprotein concentrations after 8 weeks suggest that a moderately restricted 
      carbohydrate diet (20% CHO as energy) can promote a less atherogenic lipid 
      profile when compared to the low-fat diet.
FAU - Stoernell, Colene K
AU  - Stoernell CK
AD  - Country Villa Health Services, Arcadia, CA 90017, USA.
FAU - Tangney, Christy C
AU  - Tangney CC
FAU - Rockway, Susie W
AU  - Rockway SW
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Lipoproteins)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - C-Reactive Protein/*analysis
MH  - *Diet, Carbohydrate-Restricted
MH  - *Diet, Fat-Restricted
MH  - Fasting
MH  - Female
MH  - Humans
MH  - Hypertriglyceridemia/blood/*diet therapy
MH  - Lipoproteins/*blood
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Middle Aged
MH  - Patient Compliance
MH  - Satiation
MH  - Triglycerides/blood
EDAT- 2008/12/17 09:00
MHDA- 2009/03/07 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/01/11 00:00 [received]
PHST- 2008/03/09 00:00 [revised]
PHST- 2008/03/14 00:00 [accepted]
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
AID - S0271-5317(08)00069-9 [pii]
AID - 10.1016/j.nutres.2008.03.013 [doi]
PST - ppublish
SO  - Nutr Res. 2008 Jul;28(7):443-9. doi: 10.1016/j.nutres.2008.03.013.