PMID- 19083485
OWN - NLM
STAT- MEDLINE
DCOM- 20090305
LR  - 20171116
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 28
IP  - 11
DP  - 2008 Nov
TI  - Association of homocysteinemia with high concentrations of serum insulin and uric 
      acid in Brazilian subjects with metabolic syndrome genotyped for C677T 
      polymorphism in the methylenetetrahydrofolate reductase gene.
PG  - 760-6
LID - 10.1016/j.nutres.2008.09.006 [doi]
AB  - Information on plasma homocysteine concentrations and their associated factors in 
      Brazilian subjects with metabolic syndrome (MS) is nonexistent. Therefore, a 
      cross-sectional study was conducted to investigate the association of 
      homocysteinemia with MS components; folate and cobalamin biochemical and dietary 
      indices of nutritional status; and genetic, anthropometric, and lifestyle factors 
      in Brazilian subjects with MS. Waist circumference; body fat; body mass index; 
      insulin resistance; lipid profiles; glycemia; uricemia; insulinemia; erythrocyte 
      folate and plasma homocysteine; folate and cobalamin concentrations; C677T 
      polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene; coffee and 
      alcohol intake; and smoking were determined in 63 subjects (24 males and 39 
      females) with MS. No difference in homocysteine plasma was observed between 
      sexes. Hyperhomocysteinemia (Hhcy) frequency was 49.2% (n = 31) in the group 
      studied. The distribution of MTHFR genotypes was as follows: CC, 64% (n = 42); 
      CT, 32% (n = 19); and TT, 4% (n = 2). No association was found between Hhcy and 
      C677T polymorphism in the MTHFR gene. Plasma homocysteine concentrations showed 
      no association with age; blood pressure; dietary intakes of folate, cobalamin, 
      and pyridoxine; body mass index; waist circumference; body fat; glycemia; lipid 
      profile; insulin resistance; and concentrations of folate erythrocyte and plasma 
      folate and cobalamin. Also, there was no correlation between Hhcy, sex, and 
      lifestyle factors. In this study, the variables uricemia (C = 0.67, chi(2) = 
      2.23, P = .27) and insulinemia (C = 0.86, chi(2) = 2.98, P = .07) were positively 
      associated with homocysteinemia. In conclusion, our results suggest that high 
      concentrations of serum insulin and uric acid are associated with an increased 
      risk of developing Hhcy in subjects with MS.
FAU - Uehara, Sofia Kimi
AU  - Uehara SK
AD  - Nutrition and Dietetic Department, Instituto de Nutricao Josue de Castro, 
      Universidade Federal do Rio de Janeiro, CEP 21941-590 Rio de Janeiro, RJ, Brazil.
FAU - Rosa, Glorimar
AU  - Rosa G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Insulin)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Brazil
MH  - Cross-Sectional Studies
MH  - Female
MH  - Folic Acid Deficiency/complications
MH  - Genotype
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Insulin/*blood
MH  - Logistic Models
MH  - Male
MH  - Metabolic Syndrome/blood/*complications/genetics
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Uric Acid/*blood
MH  - Vitamin B 12 Deficiency/complications
EDAT- 2008/12/17 09:00
MHDA- 2009/03/06 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/07/27 00:00 [received]
PHST- 2008/09/09 00:00 [revised]
PHST- 2008/09/10 00:00 [accepted]
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/03/06 09:00 [medline]
AID - S0271-5317(08)00198-X [pii]
AID - 10.1016/j.nutres.2008.09.006 [doi]
PST - ppublish
SO  - Nutr Res. 2008 Nov;28(11):760-6. doi: 10.1016/j.nutres.2008.09.006.