PMID- 19083989
OWN - NLM
STAT- MEDLINE
DCOM- 20090220
LR  - 20090209
IS  - 1873-6254 (Electronic)
IS  - 0001-706X (Linking)
VI  - 109
IP  - 3
DP  - 2009 Mar
TI  - Serum levels of sTNF-R1, sTNF-R2 and CXCL9 correlate with disease activity in 
      adult type paracoccidioidomycosis.
PG  - 213-8
LID - 10.1016/j.actatropica.2008.11.010 [doi]
AB  - Paracoccidioidomycosis (PCM) is the most common systemic mycosis in Latin 
      America. A major problem in the management of PCM is to determine the best time 
      to discontinue therapy due to the high relapse rate among patients. Soluble TNF 
      receptors (sTNF-R) levels and chemokines are associated with disease activity in 
      several infectious, inflammatory and autoimmune disorders. The aim of the present 
      work was to evaluate levels of sTNF-R1, sTNF-R2 and chemokines in serum of 
      patients with adult type of PCM, before and after antifungal therapy, and to 
      correlate those levels to disease activity. Concentrations of sTNF-R1, sTNF-R2 
      and CXCL9 were higher in untreated patients and decreased progressively with 
      treatment. The serum marker with the best accuracy to discriminate PCM cases from 
      controls was sTNF-R2. sTNF-R1 did not drop to control levels before 36 months of 
      treatment. CCL2 and CCL3 levels were low at baseline in PCM patients, raised 
      significantly after 12 months of treatment and diminished thereafter. CCL24 
      levels were higher after 36 months of antifungal therapy in PCM patients. CCL11 
      levels were not statistically different from control subjects. sTNF-R1, sTNF-R2 
      and CXCL9 may be useful as laboratory parameters to assess disease activity in 
      PCM patients.
FAU - Lyon, Ana C
AU  - Lyon AC
AD  - Department of Internal Medicine, Faculty of Medicine, Federal University of Minas 
      Gerais, Avenida Alfredo Balena 190, Santa Efigenia, Belo Horizonte, MG, Brazil.
FAU - Teixeira, Mauro M
AU  - Teixeira MM
FAU - Araujo, Stanley A
AU  - Araujo SA
FAU - Pereira, Maria C N
AU  - Pereira MC
FAU - Pedroso, Enio R P
AU  - Pedroso ER
FAU - Teixeira, Antonio L
AU  - Teixeira AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081125
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL24 protein, human)
RN  - 0 (CCL3 protein, human)
RN  - 0 (CXCL9 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL24)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CXCL9)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
SB  - IM
MH  - Adult
MH  - Brazil
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL24
MH  - Chemokine CCL3/blood
MH  - Chemokine CXCL9/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioidomycosis/drug therapy/*immunology/*pathology
MH  - Receptors, Tumor Necrosis Factor, Type I/*blood
MH  - Receptors, Tumor Necrosis Factor, Type II/*blood
MH  - Serum/chemistry
EDAT- 2008/12/17 09:00
MHDA- 2009/02/21 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/05/05 00:00 [received]
PHST- 2008/10/16 00:00 [revised]
PHST- 2008/11/14 00:00 [accepted]
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/02/21 09:00 [medline]
AID - S0001-706X(08)00329-X [pii]
AID - 10.1016/j.actatropica.2008.11.010 [doi]
PST - ppublish
SO  - Acta Trop. 2009 Mar;109(3):213-8. doi: 10.1016/j.actatropica.2008.11.010. Epub 
      2008 Nov 25.