PMID- 19084220 OWN - NLM STAT- MEDLINE DCOM- 20100105 LR - 20220318 IS - 1973-8102 (Electronic) IS - 0010-9452 (Linking) VI - 46 IP - 1 DP - 2010 Jan TI - Specific role of medial prefrontal cortex in retrieving recent autobiographical memories: an fMRI study of young female subjects. PG - 29-39 LID - 10.1016/j.cortex.2008.07.003 [doi] AB - Episodic-autobiographical memory (AM) is characterized by self-conscious reflection, emotional connotation and mental time travel. Semantic memory (SM) contains context and emotion free general knowledge. The present study specifically aimed at exploring the effect of time on the neural substrates of autobiographical and semantic memory retrieval by studying memories from different life periods in young female participants using functional brain imaging. Recent compared to early childhood events activated retrosplenial cortex. More importantly, medial prefrontal cortex (MPFC) was specifically engaged in the retrieval of recent AMs. The data show time-modulated neural substrates during recent and remote memories in women and suggest that a specific MPFC activation underlies the autonoetic, emotional and self-related character of recent AMs. FAU - Oddo, Silvia AU - Oddo S AD - Physiological Psychology, University of Bielefeld, Germany. FAU - Lux, Silke AU - Lux S FAU - Weiss, Peter H AU - Weiss PH FAU - Schwab, Anna AU - Schwab A FAU - Welzer, Harald AU - Welzer H FAU - Markowitsch, Hans J AU - Markowitsch HJ FAU - Fink, Gereon R AU - Fink GR LA - eng PT - Journal Article DEP - 20081107 PL - Italy TA - Cortex JT - Cortex; a journal devoted to the study of the nervous system and behavior JID - 0100725 SB - IM MH - Acoustic Stimulation MH - Analysis of Variance MH - Attention/physiology MH - Brain Mapping MH - Emotions/*physiology MH - Female MH - Functional Laterality/physiology MH - Humans MH - Image Processing, Computer-Assisted MH - Interviews as Topic MH - Magnetic Resonance Imaging MH - Mental Recall/*physiology MH - Neuropsychological Tests MH - Prefrontal Cortex/*physiology MH - Surveys and Questionnaires MH - Time Factors MH - Young Adult EDAT- 2008/12/17 09:00 MHDA- 2010/01/06 06:00 CRDT- 2008/12/17 09:00 PHST- 2008/01/13 00:00 [received] PHST- 2008/06/20 00:00 [revised] PHST- 2008/07/16 00:00 [accepted] PHST- 2008/12/17 09:00 [entrez] PHST- 2008/12/17 09:00 [pubmed] PHST- 2010/01/06 06:00 [medline] AID - S0010-9452(08)00250-5 [pii] AID - 10.1016/j.cortex.2008.07.003 [doi] PST - ppublish SO - Cortex. 2010 Jan;46(1):29-39. doi: 10.1016/j.cortex.2008.07.003. Epub 2008 Nov 7.