PMID- 19086199
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20081215
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 128
IP  - 9
DP  - 2008 Sep
TI  - Effects of hyperbaric oxygen therapy on facial nerve regeneration.
PG  - 1048-52
LID - 10.1080/00016480701827525 [doi]
AB  - CONCLUSION: Hyperbaric oxygen treatment (HBOT) promoted an increase of the mean 
      axonal diameter in the group evaluated 2 weeks after lesion induction, which 
      suggests a more advanced regeneration process. However, the number of myelin 
      nerve fibers of the facial nerve of the rabbits was similar when compared to the 
      control and treatment groups, in both evaluation periods. OBJECTIVE: To evaluate 
      the effect of HBOT on the histological pattern of the facial nerve in rabbits 
      exposed to a nerve crush injury. MATERIALS AND METHODS: Twenty rabbits were 
      exposed to facial nerve crush injury. Ten rabbits received HBOT, 10 rabbits 
      comprised the control group. The rabbits were sacrificed 2 and 4 weeks after the 
      trauma. Qualitative morphological analysis, measurement of the external axonal 
      diameters and myelin fiber count were carried out in an area of 185 000 microm2. 
      RESULTS: There was an increase in the area of the axons and thicker myelin in the 
      2 weeks treatment group in comparison with the control group. The mean diameter 
      of the axons was of 2.34 microm in the control group and of 2.81 microm in the 
      HBOT group, with statistically significant differences. The 2 week control group 
      had a mean number of myelin fibers of 1865.2 +/- 664, and the HBOT group had a 
      mean number of 2026.3 +/- 302; this was not statistically significant. The 4 week 
      control group presented a mean of 2495.1 +/- 479 fibers and the HBOT group 
      presented a mean of 2359.9 +/- 473; this was not statistically significant.
FAU - Vilela, Daniela Salgado Alves
AU  - Vilela DS
AD  - Otorhinolaryngology Department, Santa Casa Sao Paulo, Faculty of Medical 
      Sciences, Sao Paulo, Brazil. ceotorrino@santacasasp.org.br
FAU - Lazarini, Paulo Roberto
AU  - Lazarini PR
FAU - Da Silva, Ciro Ferreira
AU  - Da Silva CF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
SB  - IM
MH  - Animals
MH  - Axons/pathology/physiology
MH  - Facial Nerve/pathology/physiopathology
MH  - Facial Nerve Injuries/*pathology/physiopathology/*therapy
MH  - *Hyperbaric Oxygenation
MH  - Male
MH  - Myelin Sheath/pathology/physiology
MH  - Nerve Crush
MH  - *Nerve Regeneration
MH  - Rabbits
MH  - Time Factors
EDAT- 2008/12/17 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
AID - 791366698 [pii]
AID - 10.1080/00016480701827525 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2008 Sep;128(9):1048-52. doi: 10.1080/00016480701827525.