PMID- 19086646
OWN - NLM
STAT- MEDLINE
DCOM- 20090511
LR  - 20161124
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 33
IP  - 16
DP  - 2008 Aug
TI  - [Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes 
      mellitus rats].
PG  - 2026-8, 2060
AB  - OBJECTIVE: To observe the effects of puerarin on ADRP gene mRNA expression in 
      fatty tissue of type 2 diabetes mellitus rats (T2DM). METHOD: Wiastar rats of 
      T2DM model were made by feeding with high glucose and fat diet and injecting with 
      small dose of streptozocin (25 mg x kg(-1)). 40 model rats were randomly divided 
      into model control group and three puerarin groups (40, 80, 160 mg x kg(-1)), 
      another 10 rats were selected as normal control group. FBG and FINS were measured 
      to calculate IR after rats were injected consecutively for 6 weeks. The level of 
      ADRP gene mRNA in fatty tissue was determined by RT-PCR after rats were injected 
      eight weeks. RESULT: Compared with model control group, high and middle dosage of 
      puerarin can decreased ADRP gene mRNA expression in fatty tissue obviously, FBG, 
      IR level in each puerarin group and FINS in high and middle dosage puerarin 
      groups decreased obviously. CONCLUSION: Puerarin can decrease the blood glucose 
      level of T2DM by downregulating ADRP mRNA expression and depressing the insulin 
      resistance.
FAU - Sun, Wei
AU  - Sun W
AD  - Physiology Department of Mudanjiang Medical College, Heilongfiang Mudanjiang 
      157011, China. sunwei-36@126.com
FAU - Zheng, Xue-zhi
AU  - Zheng XZ
FAU - Xu, Qiu-ling
AU  - Xu QL
FAU - Nian, Hong
AU  - Nian H
FAU - Liu, Gui-lian
AU  - Liu GL
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Blood Glucose)
RN  - 0 (Isoflavones)
RN  - 0 (Membrane Proteins)
RN  - 0 (Perilipin-2)
RN  - 0 (Plin2 protein, rat)
RN  - 0 (Vasodilator Agents)
RN  - Z9W8997416 (puerarin)
SB  - IM
MH  - Adipose Tissue/*drug effects/metabolism
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Diabetes Mellitus, Experimental/*drug therapy/genetics
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - In Vitro Techniques
MH  - Isoflavones/*pharmacology
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Perilipin-2
MH  - Rats
MH  - Rats, Wistar
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Vasodilator Agents/*pharmacology
EDAT- 2008/12/18 09:00
MHDA- 2009/05/12 09:00
CRDT- 2008/12/18 09:00
PHST- 2008/12/18 09:00 [entrez]
PHST- 2008/12/18 09:00 [pubmed]
PHST- 2009/05/12 09:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(16):2026-8, 2060.