PMID- 19086654
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20081217
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 17
DP  - 2008 Sep
TI  - [Expression of angiopoietin-1,2 and its relationship with angiogenesis in 
      laryngeal squamous cell carcinoma].
PG  - 772-6
AB  - OBJECTIVE: To investigate the expression of Angiopoietin-1,2 in laryngeal 
      squamous cell carcinoma (LSCC) and the relationship between Angiopoietin-1,2 
      expression and clinicopathologic parameters and microvessel density (MVD) marked 
      by CD105, and also evaluate the significance of co-expression of Ang-2 and 
      vascular endothelial cell growth factor (VEGF) in tumor angiogenesis. METHOD: The 
      expression of Ang-1,2 and VEGF in samples of tumor, para cancer and normal mucosa 
      were detected by immunohistochemical method. RESULT: The expression of 
      Angiopoietin-1,2 were identified in LSCC, para cancer tissue and normal mucosa. 
      The VEGF expression was only existed in LSCC. The expression of Ang-1,2 were 
      significantly higher in LSCC than in para cancer tissue (P < 0.05) and normal 
      mucosa (P < 0.01). In the clinicopathologic parameters, only the expression of 
      Ang-2 was closely correlated with clinical stages and MVD (all P < 0.05). There 
      was no significant correlation between the expression of Ang-1,2 and tumor 
      differentiation degree (all P > 0.05). When the expression of Ang-2 and VEGF were 
      both positive, the mean value of MVD was higher than others (P < 0.05). 
      CONCLUSION: These results suggest that overexpression of Ang-1,2 may play a very 
      important role in the development of LSCC and are closely correlated with 
      angiogenesis. Ang-2 promote angiogenesis when interacting with VEGF.
FAU - Xu, Guang
AU  - Xu G
AD  - Department of Otolaryngology, First Hospital of Zhengzhou University, Zhengzhou 
      450052, China.
FAU - Lou, Weihua
AU  - Lou W
FAU - Sun, Zhanwei
AU  - Sun Z
FAU - Zhang, Peng
AU  - Zhang P
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Angiopoietin-1)
RN  - 0 (Angiopoietin-2)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Aged
MH  - Angiopoietin-1/*metabolism
MH  - Angiopoietin-2/*metabolism
MH  - Carcinoma, Squamous Cell/*blood supply/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*blood supply/metabolism/pathology
MH  - Male
MH  - Microcirculation
MH  - Middle Aged
MH  - Neovascularization, Pathologic
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2008/12/18 09:00
MHDA- 2011/06/17 06:00
CRDT- 2008/12/18 09:00
PHST- 2008/12/18 09:00 [entrez]
PHST- 2008/12/18 09:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Sep;22(17):772-6.