PMID- 19087226 OWN - NLM STAT- MEDLINE DCOM- 20090115 LR - 20240312 IS - 1365-2893 (Electronic) IS - 1352-0504 (Print) IS - 1352-0504 (Linking) VI - 15 IP - 12 DP - 2008 Dec TI - Predictors of insulin resistance among Hispanic adults infected with or at risk of infection with the human immunodeficiency virus and hepatitis C virus. PG - 878-87 LID - 10.1111/j.1365-2893.2008.01021.x [doi] AB - Both the human immunodeficiency (HIV) and hepatitis C (HCV) viruses have been associated with insulin resistance (IR). However, our understanding of the prevalence of IR, the underlying mechanisms and predisposing factors is limited, particularly among minority populations. We conducted a study of 333 Hispanic adults including: 76 HIV monoinfected, 62 HCV monoinfected, 97 HIV/HCV co-infected and 98 uninfected controls with a specific focus on HCV infection and liver injury as possible predictors of IR. IR was measured using the Quantitative Insulin Sensitivity Check Index (QUICKI). The majority (55-69%) of participants in all groups had QUICKI values <0.350. Body mass index was associated with IR in all groups. Triglycerides were associated with IR in the uninfected control group only (-1.83, SE = 0.58, P = 0.0022). HCV was associated with IR in participants infected with HIV (-0.012, SE = 0.0046, P = 0.010). Liver injury, as measured by score to assess liver injury (FIB-4) score, was significantly associated with IR independently of HCV infection (-0.0035, SE = 0.0016, P = 0.027). In the HIV/HCV co-infected group, treatment with nucleoside reverse-transcriptase (RT) inhibitors plus non-nucleoside RT inhibitors (-0.021, SE = 0.080, P = 0.048), but not protease inhibitors (-0.000042, SE = 0.0082, P = 0.96) was associated with IR. HCV infection and antiretroviral agents, including nucleoside RT inhibitor plus non-nucleoside RT inhibitor treatment are contributors to IR in HIV infection. Liver injury, as measured by the FIB-4 score, is a predictor of IR independently of HCV infection. FAU - Castaneda-Sceppa, C AU - Castaneda-Sceppa C AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA. FAU - Bermudez, O I AU - Bermudez OI FAU - Wanke, C AU - Wanke C FAU - Forrester, J E AU - Forrester JE LA - eng GR - R01 DA011598-10/DA/NIDA NIH HHS/United States GR - R01 DA014501/DA/NIDA NIH HHS/United States GR - P01 DK045734/DK/NIDDK NIH HHS/United States GR - M01 RR000054/RR/NCRR NIH HHS/United States GR - P30 DA013868/DA/NIDA NIH HHS/United States GR - R01 DA011598/DA/NIDA NIH HHS/United States PT - Journal Article PL - England TA - J Viral Hepat JT - Journal of viral hepatitis JID - 9435672 SB - IM MH - Adult MH - Cohort Studies MH - Female MH - HIV MH - HIV Infections/*complications/drug therapy/*ethnology/virology MH - Hepatitis C/*complications/drug therapy/*ethnology/virology MH - *Hispanic or Latino MH - Humans MH - *Insulin Resistance MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Prospective Studies MH - Risk Factors MH - United States PMC - PMC2784594 MID - NIHMS137061 EDAT- 2008/12/18 09:00 MHDA- 2009/01/16 09:00 PMCR- 2009/11/27 CRDT- 2008/12/18 09:00 PHST- 2008/12/18 09:00 [entrez] PHST- 2008/12/18 09:00 [pubmed] PHST- 2009/01/16 09:00 [medline] PHST- 2009/11/27 00:00 [pmc-release] AID - JVH1021 [pii] AID - 10.1111/j.1365-2893.2008.01021.x [doi] PST - ppublish SO - J Viral Hepat. 2008 Dec;15(12):878-87. doi: 10.1111/j.1365-2893.2008.01021.x.