PMID- 19087491
OWN - NLM
STAT- MEDLINE
DCOM- 20111021
LR  - 20081217
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 43
IP  - 8
DP  - 2008 Aug
TI  - [Preimplantation genetic diagnosis of translocation].
PG  - 581-3
AB  - OBJECTIVES: To observe the genetic characteristics of chromosomes and the rates 
      of implantation and pregnancy in couples of translocation carriers who undergo 
      preimplantation genetic diagnosis (PGD) and to evaluate the significance of PGD 
      in the treatment of translocation carriers. METHODS: Fluorescence in situ 
      hybridization (FISH) was performed to analyze the embryos of 12 carriers of 
      reciprocal translocation and 22 carriers of Robertsonian translocation. The 
      results of diagnosis and the implantation and pregnancy rates were analyzed. 
      RESULTS: A total of 253 embryos from 36 couples were retrieved and FISH was 
      applied for the examination. The characteristics of chromosomes were diagnosed in 
      225 embryos and the rate of successful PGD was 88.9%. Fifty-eight embryos were 
      found to have normal chromosome or balanced translocation and were transferred 
      into the uterus. The rate of implantation was 36% (5/14) and 14% (6/44) and the 
      rate of pregnancy was 4/9 and 26% (5/19) for carriers of Robertsonian 
      translocation and reciprocal translocation, respectively. CONCLUSIONS: The 
      FISH-based PGD is effective in the diagnosis of Robertsonian translocation and 
      reciprocal translocation of embryos. It provides the possibility of a high rate 
      of implantation and pregnancy, and avoids recurrent abortion and unwilling 
      termination of pregnancy.
FAU - Qian, Yu-Li
AU  - Qian YL
AD  - Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, 
      Zhejiang University, Hangzhou 310006, China.
FAU - Xu, Chen-Ming
AU  - Xu CM
FAU - Jin, Fan
AU  - Jin F
FAU - Zhu, Yi-Min
AU  - Zhu YM
FAU - Luo, Qiong
AU  - Luo Q
FAU - Huang, He-Feng
AU  - Huang HF
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
SB  - IM
MH  - Abortion, Spontaneous/genetics/prevention & control
MH  - Embryo Implantation
MH  - Female
MH  - Fertilization in Vitro
MH  - Heterozygote
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Infertility/genetics
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Preimplantation Diagnosis/*methods
MH  - *Translocation, Genetic
EDAT- 2008/12/18 09:00
MHDA- 2011/10/22 06:00
CRDT- 2008/12/18 09:00
PHST- 2008/12/18 09:00 [entrez]
PHST- 2008/12/18 09:00 [pubmed]
PHST- 2011/10/22 06:00 [medline]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2008 Aug;43(8):581-3.