PMID- 19087700
OWN - NLM
STAT- MEDLINE
DCOM- 20090520
LR  - 20081217
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 88
IP  - 33
DP  - 2008 Aug 26
TI  - [Ischemic postconditioning induces neuroprotection via up-regulation of 
      endogenous antioxidant enzyme activities: experiment with rabbits].
PG  - 2355-9
AB  - OBJECTIVE: To test the hypothesis that spinal cord protection induced by ischemic 
      postconditioning is mediated by an increase of endogenous antioxidant enzyme 
      activities during reperfusion phase in spinal cord. METHODS: Seventy-eight male 
      New Zealand rabbits were randomly divided into 3 groups: Sham group (n = 18) 
      undergoing sham operation without aortic occlusion; ischemia/reperfusion (I/R) 
      group (n = 30) undergoing occlusion of the infrarenal abdominal aorta for 20 min, 
      followed by reperfusion; and postconditioning (PostC) group (n = 30) undergoing 
      occlusion of the infrarenal abdominal aorta for 20 min followed by 3 cycles of 30 
      s reperfusion/30 s ischemia just at the onset of reperfusion. 30 min, and 1, 3, 
      6, 24, and 48 h after reperfusion 5 rabbits from each group (and 3 from the Sham 
      group) were killed with their spinal cords taken out, and spectrophotometric 
      method was used to determine the antioxidant enzyme activity and malondialdehyde 
      (MDA) content 6, 24, and 48 h after reperfusion motor function scoring of the 
      hind limbs was conducted. RESULTS: (1) The motor function scores of the PostC 
      group were significantly higher than those of the I/R group 6, 24, and 48 h after 
      reperfusion (all P < 0.05). (2) The activities of superoxide dismutase (SOD) and 
      catalase (CAT) in the spinal cord tissue of the PostC group 30 min-6 h after 
      reperfusion were all significantly higher than those of the I/R group (all P < 
      0.05). There were no significant differences in the activity of glutathione 
      peroxidase (GSH-px) at different time points between the PostC and I/R groups. 
      (3) The MDA levels 24 h and 48 h after reperfusion of the PostC group were both 
      significantly lower than that of the I/R group (both P < 0.01). CONCLUSION: 
      Ischemic postconditioning shows effect against spinal cord ischemic-reperfusion 
      injury mediated, at least partially, by up-regulating the activities of SOD and 
      CAT in spinal cord during early reperfusion phase.
FAU - Song, Wen-ying
AU  - Song WY
AD  - Department of Anesthesiology, Xijing Hospital, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Dong, Hai-long
AU  - Dong HL
FAU - Cheng, Qiong
AU  - Cheng Q
FAU - Lu, Zhi-hong
AU  - Lu ZH
FAU - Wang, Hui
AU  - Wang H
FAU - Meng, Jing-ru
AU  - Meng JR
FAU - Xiong, Li-ze
AU  - Xiong LZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Antioxidants)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Catalase/metabolism
MH  - Disease Models, Animal
MH  - Ischemic Preconditioning/*methods
MH  - Male
MH  - Rabbits
MH  - Reperfusion Injury/*metabolism/*prevention & control
MH  - Spinal Cord Ischemia/*metabolism/*prevention & control
MH  - Superoxide Dismutase/metabolism
MH  - Up-Regulation
EDAT- 2008/12/18 09:00
MHDA- 2009/05/21 09:00
CRDT- 2008/12/18 09:00
PHST- 2008/12/18 09:00 [entrez]
PHST- 2008/12/18 09:00 [pubmed]
PHST- 2009/05/21 09:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2008 Aug 26;88(33):2355-9.