PMID- 19092090
OWN - NLM
STAT- MEDLINE
DCOM- 20090106
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 250
IP  - 1
DP  - 2009 Jan
TI  - Determination of regional ejection fraction in patients with myocardial 
      infarction by using merged late gadolinium enhancement and cine MR: feasibility 
      study.
PG  - 50-60
LID - 10.1148/radiol.2493080340 [doi]
AB  - PURPOSE: To quantify regional ejection fraction (EF) in patients with myocardial 
      infarction (MI) by using merged late gadolinium enhancement (LGE) and cine 
      magnetic resonance (MR) imaging, and compare this method with the standardized 
      17-segment American Heart Association approach. MATERIALS AND METHODS: After 
      institutional review board approval and informed consent, 15 MI patients (14 men, 
      one woman; mean age, 63 years +/- 10 [standard deviation]) were studied at 1 week 
      and at 4 months after MI. Short-axis LGE MR information was used to quantify 
      infarct size, and to divide the left ventricle (LV) on short-axis cine MR images 
      in infarct, periinfarct, and remote regions by using a fixed-center method, 
      yielding information on regional volumes, regional EFs, systolic wall thickening 
      (SWT), and systolic wall motion (SWM). This approach was compared with a 
      floating-center approach and the 17-segment approach. RESULTS: Mean infarct size 
      (normalized to LV mass) was 25% +/- 14 at 1 week and 16% +/- 8 at 4 months (P < 
      .001). At 4 months, LV EF significantly improved (mean, 47.9% +/- 5.9 vs 50.9% 
      +/- 6.6, P = .031), matching an improvement of regional EF (mean, 17.1% +/- 11.5 
      vs 24.6% +/- 13.1, P = .005) and SWM (mean, 3.2 mm +/- 1.7 vs 3.9 mm +/- 2.1, P = 
      .027) in the infarcted myocardium. No significant changes in regional EF, SWT, or 
      SWM occurred in the remote myocardium. Regional EF estimates correlated well with 
      SWT and SWM (both r = 0.92, P < .001). The floating-center method invariably 
      underestimated regional EF (mean, -20.8% +/- 7.6; 95% confidence interval: 
      -23.7%, -17.9%), especially with increasing infarct size. By using the 17-segment 
      approach, no functional improvement was shown in the infarcted myocardium. 
      CONCLUSION: Assessment of regional ventricular performance (regional EF) in 
      well-defined areas (eg, infarcted and remote myocardium) is feasible by using 
      merged LGE and cine MR imaging.
CI  - (c) RSNA, 2009.
FAU - Masci, Pier Giorgio
AU  - Masci PG
AD  - Department of Radiology, University Hospitals of Leuven, Herestraat 49, B-3000 
      Leuven, Belgium.
FAU - Dymarkowski, Steven
AU  - Dymarkowski S
FAU - Rademakers, Frank E
AU  - Rademakers FE
FAU - Bogaert, Jan
AU  - Bogaert J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media/administration & dosage
MH  - Feasibility Studies
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/physiology
MH  - Myocardial Infarction/diagnosis/*physiopathology
MH  - Myocardium/pathology
MH  - Observer Variation
MH  - Sensitivity and Specificity
MH  - Stroke Volume/*physiology
MH  - Systole/physiology
MH  - Ventricular Dysfunction, Left/diagnosis/physiopathology
EDAT- 2008/12/19 09:00
MHDA- 2009/01/07 09:00
CRDT- 2008/12/19 09:00
PHST- 2008/12/19 09:00 [entrez]
PHST- 2008/12/19 09:00 [pubmed]
PHST- 2009/01/07 09:00 [medline]
AID - 250/1/50 [pii]
AID - 10.1148/radiol.2493080340 [doi]
PST - ppublish
SO  - Radiology. 2009 Jan;250(1):50-60. doi: 10.1148/radiol.2493080340.