PMID- 19092784
OWN - NLM
STAT- MEDLINE
DCOM- 20090803
LR  - 20150311
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Linking)
VI  - 34
IP  - 7
DP  - 2009 Jun
TI  - Involvement of inferior parietal lobules in prospective memory impairment during 
      acute MDMA (ecstasy) intoxication: an event-related fMRI study.
PG  - 1641-8
LID - 10.1038/npp.2008.219 [doi]
AB  - Prospective memory refers to the realization of delayed intentions. Several 
      studies have shown that 3,4-methylenedioxy-methamphetamine (MDMA) users perform 
      worse on measures of prospective memory as compared to nondrug users. 
      Interpretation of these data may be limited because of polydrug use, psychosocial 
      stressors, and increased psychopathology that have been reported in MDMA users. 
      This study was designed to directly assess the pharmacological effect of MDMA on 
      prospective memory and brain activity in a double-blind, placebo-controlled, 
      cross-over study. Twelve recreational MDMA users received MDMA 75 mg and placebo 
      and performed an objective prospective memory task during functional imaging. 
      During prospective memory task performance subjects were engaged in a foreground 
      task that consisted of a simple reaction time to visual stimuli (Go trials) and a 
      prospective task of withholding a response during trials that were part of a 
      dynamic memory set (No go trials). Behavioral data showed that a single dose of 
      MDMA increased prospective memory failures in the No go trials, and that number 
      of prospective memory failures was positively correlated to MDMA concentration in 
      plasma. Functional imaging showed that MDMA decreased BOLD activation during Go 
      trials in the thalamus (left), putamen (left), precuneus (left), and the inferior 
      parietal lobules (bilateral), as compared to placebo. During No go trials, MDMA 
      reduced BOLD deactivation in the inferior parietal lobules (bilateral), as 
      compared to placebo. It is concluded that the loss of deactivation in inferior 
      parietal lobules may account for increments in memory failures observed during 
      MDMA intoxication.
FAU - Ramaekers, Johannes G
AU  - Ramaekers JG
AD  - Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and 
      Neuroscience, Maastricht University, Maastricht, The Netherlands. 
      j.ramaekers@psychology.unimaas.nl
FAU - Kuypers, Kim P C
AU  - Kuypers KP
FAU - Wingen, Marleen
AU  - Wingen M
FAU - Heinecke, Armin
AU  - Heinecke A
FAU - Formisano, Elia
AU  - Formisano E
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20081217
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - S88TT14065 (Oxygen)
SB  - IM
EIN - Neuropsychopharmacology. 2009 Jun;34(7):1883-4
MH  - Adult
MH  - Analysis of Variance
MH  - Brain Mapping
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Electroencephalography
MH  - Evoked Potentials, Visual/*drug effects
MH  - Female
MH  - Hallucinogens/blood/*toxicity
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory Disorders/blood/*chemically induced/*pathology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/blood/*toxicity
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - *Parietal Lobe/blood supply/drug effects/physiopathology
MH  - Reaction Time/drug effects
MH  - Young Adult
EDAT- 2008/12/19 09:00
MHDA- 2009/08/04 09:00
CRDT- 2008/12/19 09:00
PHST- 2008/12/19 09:00 [entrez]
PHST- 2008/12/19 09:00 [pubmed]
PHST- 2009/08/04 09:00 [medline]
AID - npp2008219 [pii]
AID - 10.1038/npp.2008.219 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2009 Jun;34(7):1641-8. doi: 10.1038/npp.2008.219. Epub 
      2008 Dec 17.