PMID- 19095221
OWN - NLM
STAT- MEDLINE
DCOM- 20090519
LR  - 20131121
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 65
IP  - 5
DP  - 2009 Mar 1
TI  - The role of the galaninergic system in modulating stress-related responses in an 
      animal model of posttraumatic stress disorder.
PG  - 383-91
LID - 10.1016/j.biopsych.2008.10.034 [doi]
AB  - BACKGROUND: Converging evidence implicates the regulatory neuropeptide galanin in 
      anxiety- and depression-related behaviors, through modulation of neuroendocrine, 
      serotonergic, and noradrenergic systems. This study examined the relationship 
      between stress-induced posttraumatic stress disorder (PTSD)-like behavioral 
      response patterns in rats and galanin mRNA levels in key brain areas and the 
      effects of acute phase pharmacologic manipulation using an agonist (galnon) on 
      behavioral, physiologic, and response patterns of brain-derived neurotrophic 
      factor (BDNF) and 5-hydroxytryptamine-1A (5HT-1A). METHOD: Galanin mRNA 
      expression was assessed in the frontal cortex and hippocampus in the short- and 
      long-term (30 min and 7 days) after exposure to predator scent stress. The 
      effects of intraperitoneal galnon .5 mg/kg versus saline 1 hour postexposure on 
      behavioral tests (elevated plus maze and acoustic startle response) were 
      evaluated 7 days later. Trauma-cue response, circulating corticosterone, and 
      localized brain expression of 5HT-1A receptors and BDNF were subsequently 
      assessed. All data were analyzed in relation to individual behavior patterns. 
      RESULTS: Whereas animals with minimal behavioral disruption displayed a lasting 
      upregulation of galanin mRNA in the hippocampal CA1 area, those with extreme 
      behavioral responses displayed downregulation in both CA1 and frontal cortex. 
      Immediate postexposure treatment with galnon significantly reduced prevalence 
      rates of extreme responders, reduced trauma-cue freezing responses, corrected the 
      corticosterone response, and increased CA1 expression of 5HT-1A and BDNF mRNA 
      compared with saline controls. CONCLUSIONS: Galanin is actively involved in the 
      neurobiological response to predator scent stress with resilience/recovery after 
      stress exposure and thus warrants further study as a potential therapeutic avenue 
      for the treatment of anxiety-related disorders.
FAU - Kozlovsky, Nitsan
AU  - Kozlovsky N
AD  - State of Israel Ministry of Health, Anxiety and Stress Research Unit, Faculty of 
      Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
FAU - Matar, Michael A
AU  - Matar MA
FAU - Kaplan, Zeev
AU  - Kaplan Z
FAU - Zohar, Joseph
AU  - Zohar J
FAU - Cohen, Hagit
AU  - Cohen H
LA  - eng
PT  - Journal Article
DEP - 20081218
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (7-((9-fluorenylmethoxycarbonyl)cyclohexylalanyllysyl)amino-4-methylcoumarin)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Coumarins)
RN  - 0 (RNA, Messenger)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 88813-36-9 (Galanin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/antagonists & inhibitors/blood
MH  - Coumarins/pharmacology
MH  - Disease Models, Animal
MH  - Down-Regulation
MH  - Frontal Lobe/metabolism
MH  - Galanin/antagonists & inhibitors/genetics/*physiology
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/metabolism
MH  - Stress Disorders, Post-Traumatic/metabolism/*physiopathology/psychology
MH  - *Stress, Psychological
MH  - Up-Regulation
EDAT- 2008/12/20 09:00
MHDA- 2009/05/20 09:00
CRDT- 2008/12/20 09:00
PHST- 2008/07/25 00:00 [received]
PHST- 2008/10/05 00:00 [revised]
PHST- 2008/10/07 00:00 [accepted]
PHST- 2008/12/20 09:00 [entrez]
PHST- 2008/12/20 09:00 [pubmed]
PHST- 2009/05/20 09:00 [medline]
AID - S0006-3223(08)01323-1 [pii]
AID - 10.1016/j.biopsych.2008.10.034 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2009 Mar 1;65(5):383-91. doi: 10.1016/j.biopsych.2008.10.034. 
      Epub 2008 Dec 18.