PMID- 19096254
OWN - NLM
STAT- MEDLINE
DCOM- 20090203
LR  - 20170309
IS  - 1598-9992 (Print)
IS  - 1598-9992 (Linking)
VI  - 52
IP  - 6
DP  - 2008 Dec
TI  - [Clinical outcomes of lamivudine therapy and HLA alleles in chronic hepatitis B 
      patients].
PG  - 368-75
AB  - BACKGROUND/AIMS: The human leukocyte antigen (HLA) system is an integral 
      component of immune response. Highly polymorphic HLA genes may play a pivotal 
      role in the response of antiviral therapy. We investigated the effects of HLA 
      gene polymorphism on the clinical outcome of chronic hepatitis B patients who 
      received lamivudine treatment. METHODS: Depending on their clinical response to 
      lamivudine therapy, a total of sixty one patients were divided into following 
      groups; non-responders, viral breakthroughers, relapsers, and seroconverters. 
      HLA-A, -B, -Cw, -DRB and HLA-DRB1 alleles typing was performed on each group 
      through the polymerase chain reaction and the sequence-specific oligonucleotide 
      hybridization method. The distribution patterns of HLA-A, HLA-B, HLA-Cw, HLA-DRB, 
      and HLA-DRB1 were then analysed. RESULTS: When non-responders were compared to 
      the other groups, high frequencies in HLA-Cw1, HLA-DRB14 and HLA-DRB4 (p=0.015, 
      0.033 and 0.004 respectively) were evident. When seroconverters were compared to 
      viral breakthroughers, high frequencies in HLA-A2 and HLA-DRB4 (p=0.048, 0.025 
      respectively) were evident. CONCLUSIONS: Our data suggests that HLA-A2, HLA-Cw1, 
      HLA-DRB14 genes are related to the clinical outcomes of lamivudine treatment in 
      chronic hepatitis B patients. These genes may be used in the prediction of the 
      clinical outcome of lamivudine therapy in chronic hepatitis B patients.
FAU - Oh, Ji Min
AU  - Oh JM
AD  - Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
FAU - Kwon, Kyu Heum
AU  - Kwon KH
FAU - Kim, Jang Eon
AU  - Kim JE
FAU - Choi, Jin Ho
AU  - Choi JH
FAU - Beom, Sun Hee
AU  - Beom SH
FAU - Lee, Sang Hyuk
AU  - Lee SH
FAU - Lee, Yong Jik
AU  - Lee YJ
FAU - Park, Mi Young
AU  - Park MY
FAU - Jung, Mee Kyung
AU  - Jung MK
FAU - Lee, Kye Heui
AU  - Lee KH
LA  - kor
PT  - English Abstract
PT  - Journal Article
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA Antigens)
RN  - 2T8Q726O95 (Lamivudine)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Antiviral Agents/*administration & dosage
MH  - Drug Resistance, Viral
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Hepatitis B virus/drug effects
MH  - Hepatitis B, Chronic/*drug therapy
MH  - Humans
MH  - Lamivudine/*administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Treatment Outcome
EDAT- 2008/12/20 09:00
MHDA- 2009/02/04 09:00
CRDT- 2008/12/20 09:00
PHST- 2008/12/20 09:00 [entrez]
PHST- 2008/12/20 09:00 [pubmed]
PHST- 2009/02/04 09:00 [medline]
AID - 200812255 [pii]
PST - ppublish
SO  - Korean J Gastroenterol. 2008 Dec;52(6):368-75.