PMID- 19098388
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20190911
IS  - 1347-8613 (Print)
IS  - 1347-8613 (Linking)
VI  - 108
IP  - 4
DP  - 2008 Dec
TI  - Basic and translational research on proteinase-activated receptors: 
      proteinase-activated receptors in female reproductive tissues and endometriosis.
PG  - 422-5
AB  - During the menstrual cycle, dynamic morphological changes are observed in the 
      ovarian follicle and the endometrium. These changes are associated with the onset 
      of the inflammatory response in which many proteinases play various roles. 
      Thrombin-induced activation of PAR(1) (proteinase-activated receptor 1) 
      stimulates the production of interleukin-8 (IL-8) and monocyte chemoattractant 
      protein-1 (MCP-1) in human granulosa cells, suggesting a possible role for PAR(1) 
      in the ovulatory process. In the endometrium, PAR(2) expression increases during 
      the menstrual period. PAR(2) activation induces IL-8 production and cell 
      proliferation in human endometrial stromal cells. PAR(1) also stimulates 
      proinflammatory cytokine production in human endometrial stromal cells. Thus, the 
      PARs may be important in directing the dynamic changes of the endometrium. PARs 
      also appear to play a role in endometriosis, a common gynecological disease, 
      since activation of PAR(1) and PAR(2) induces the secretion of inflammatory 
      cytokines and the proliferation of stromal cells in endometriotic lesions. Taken 
      together, PARs appear to play diverse roles in the human reproductive organs.
FAU - Osuga, Yutaka
AU  - Osuga Y
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Tokyo, Japan. yutakaos-tky@umin.ac.jp
FAU - Hirota, Yasushi
AU  - Hirota Y
FAU - Taketani, Yuji
AU  - Taketani Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Cytokines)
RN  - 0 (Receptor, PAR-1)
RN  - 0 (Receptor, PAR-2)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Endometriosis/*physiopathology
MH  - Endometrium/cytology/metabolism
MH  - Female
MH  - Gene Expression Regulation
MH  - Granulosa Cells/metabolism
MH  - Humans
MH  - Ovulation/physiology
MH  - Receptor, PAR-1/*metabolism
MH  - Receptor, PAR-2/*metabolism
EDAT- 2008/12/23 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/12/23 09:00
PHST- 2008/12/23 09:00 [entrez]
PHST- 2008/12/23 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
AID - JST.JSTAGE/jphs/08R13FM [pii]
AID - 10.1254/jphs.08r13fm [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2008 Dec;108(4):422-5. doi: 10.1254/jphs.08r13fm.