PMID- 19098870
OWN - NLM
STAT- MEDLINE
DCOM- 20090224
LR  - 20081222
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Linking)
VI  - 104
IP  - 1
DP  - 2009 Jan
TI  - HLA and autoimmune digestive disease: a clinically oriented review for 
      gastroenterologists.
PG  - 195-217; quiz 194, 218
LID - 10.1038/ajg.2008.10 [doi]
AB  - OBJECTIVES: The human leukocyte antigen (HLA) system includes genes involved in 
      graft-vs-host rejection and in immune response. The discovery that HLAs are 
      associated with several diseases led to appealing developments both in basic 
      biomedical research and in clinical medicine, and offered the opportunity to 
      improve the understanding of pathogenesis and classification of diseases, as well 
      as to provide diagnostic and prognostic indicators. The aim of this article is to 
      review the association between HLA alleles and autoimmune digestive disease and 
      its current relationship with modern HLA nomenclature and clinical practice. 
      METHODS: Articles dealing with the association between HLAs and autoimmune 
      digestive disease (including celiac disease, inflammatory bowel disease, 
      autoimmune hepatitis, sclerosing cholangitis and primary biliary cirrhosis) were 
      searched for using Pubmed and SCOPUS databases from earliest records to January 
      2008. RESULTS: The review has provided two sections. In the first, we explain the 
      basic principles of HLA structure, function, and nomenclature, as an introduction 
      to the second section, which describes current associations between HLA alleles 
      and digestive diseases. The clinical implications of each HLA association are 
      critically discussed. Actually, a clinical role for HLA typing is suggested for 
      only a few conditions, e.g., celiac disease. CONCLUSIONS: The knowledge of 
      current HLA nomenclature and of its association with some digestive diseases such 
      as celiac disease can be useful in clinical practice for diagnostic and 
      prognostic purposes. This can avoid improper HLA typing as well as stressing the 
      need for further studies on other possible clinical applications.
FAU - Cassinotti, Andrea
AU  - Cassinotti A
AD  - Department of Clinical Science, Division of Gastroenterology, L. Sacco University 
      Hospital, via G.B.Grassi 74, Milan, Italy. andreacassinotti@libero.it
FAU - Birindelli, Sarah
AU  - Birindelli S
FAU - Clerici, Mario
AU  - Clerici M
FAU - Trabattoni, Daria
AU  - Trabattoni D
FAU - Lazzaroni, Marco
AU  - Lazzaroni M
FAU - Ardizzone, Sandro
AU  - Ardizzone S
FAU - Colombo, Riccardo
AU  - Colombo R
FAU - Rossi, Edoardo
AU  - Rossi E
FAU - Porro, Gabriele Bianchi
AU  - Porro GB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autoimmune Diseases/genetics/*immunology
MH  - Celiac Disease/genetics/immunology
MH  - Cholangitis, Sclerosing/genetics/immunology
MH  - Digestive System Diseases/genetics/*immunology
MH  - Genetic Predisposition to Disease
MH  - *HLA Antigens/genetics/immunology
MH  - Hepatitis, Autoimmune/genetics/immunology
MH  - Humans
MH  - Inflammatory Bowel Diseases/genetics/immunology
MH  - Liver Cirrhosis, Biliary/genetics/immunology
RF  - 270
EDAT- 2008/12/23 09:00
MHDA- 2009/02/25 09:00
CRDT- 2008/12/23 09:00
PHST- 2008/12/23 09:00 [entrez]
PHST- 2008/12/23 09:00 [pubmed]
PHST- 2009/02/25 09:00 [medline]
AID - ajg200810 [pii]
AID - 10.1038/ajg.2008.10 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2009 Jan;104(1):195-217; quiz 194, 218. doi: 
      10.1038/ajg.2008.10.