PMID- 19099095
OWN - NLM
STAT- MEDLINE
DCOM- 20090720
LR  - 20220316
IS  - 1806-3756 (Electronic)
IS  - 1806-3713 (Linking)
VI  - 34
IP  - 11
DP  - 2008 Nov
TI  - Prevalence of allergic bronchopulmonary aspergillosis in patients with cystic 
      fibrosis in the state of Bahia, Brazil.
PG  - 900-6
LID - S1806-37132008001100003 [pii]
AB  - OBJECTIVE: To determine the prevalence of allergic bronchopulmonary aspergillosis 
      (ABPA) in patients with cystic fibrosis treated at a referral center in the state 
      of Bahia, Brazil. METHODS: A cross-sectional study, with prospective data 
      collection, carried out at the Cystic Fibrosis Referral Center of Bahia of the 
      Octavio Mangabeira Specialized Hospital. We evaluated 74 patients diagnosed with 
      cystic fibrosis, older than six years of age, treated between December 9, 2003 
      and March 7, 2005. We analyzed the following variables: gender, age, forced vital 
      capacity, forced expiratory volume in one second, pharmacodynamic response, chest 
      X-ray findings, facial sinus X-ray findings, wheezing, cultures for Aspergillus 
      spp., total immunoglobulin E (IgE), specific IgE for Aspergillus fumigatus and 
      immediate skin test reactivity to A.fumigatus antigen. RESULTS: Of the 74 
      patients, 2 were diagnosed with ABPA. We found total IgE levels > 1,000 IU/mL in 
      17 (23%), positive immediate skin reactivity to A. fumigatus antigen in 19 
      (25.7%) and wheezing in 60 (81.1%). CONCLUSIONS: The prevalence of ABPA was 2.7%. 
      The high levels of total IgE, high incidence of wheezing and high rate of 
      immediate skin test reactivity to A. fumigatus antigen suggest that these 
      patients should be carefully monitored due to their propensity to develop ABPA.
FAU - Carneiro, Ana Claudia Costa
AU  - Carneiro AC
AD  - Hospital Especializado Octavio Mangabeira, Secretaria de Saude do Estado da 
      Bahia. anaclaudiaccarneiro@hotmail.com
FAU - Lemos, Antonio Carlos Moreira
AU  - Lemos AC
FAU - Arruda, Sergio Marcos
AU  - Arruda SM
FAU - Santana, Maria Angelica Pinheiro Santos
AU  - Santana MA
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - J Bras Pneumol
JT  - Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de 
      Pneumologia e Tisilogia
JID - 101222274
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aspergillosis, Allergic Bronchopulmonary/*epidemiology/immunology
MH  - Aspergillus fumigatus/immunology
MH  - Brazil/epidemiology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Cystic Fibrosis/*complications/microbiology
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Skin Tests
MH  - Young Adult
EDAT- 2008/12/23 09:00
MHDA- 2009/07/21 09:00
CRDT- 2008/12/23 09:00
PHST- 2007/11/12 00:00 [received]
PHST- 2008/04/02 00:00 [accepted]
PHST- 2008/12/23 09:00 [entrez]
PHST- 2008/12/23 09:00 [pubmed]
PHST- 2009/07/21 09:00 [medline]
AID - S1806-37132008001100003 [pii]
AID - 10.1590/s1806-37132008001100003 [doi]
PST - ppublish
SO  - J Bras Pneumol. 2008 Nov;34(11):900-6. doi: 10.1590/s1806-37132008001100003.