PMID- 19099623
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 16
IP  - 6
DP  - 2008 Dec
TI  - [Detection of chromosome 13 deletion in plasma cell leukemia by dual-color 
      fluorescence in situ hybridization].
PG  - 1261-4
AB  - This study was aimed to investigate the deletion features of chromosome 13 in 
      plasma cell leukemia (PCL) and its relationship with clinical features. The 
      dual-color fluorescence in situ hybridization (FISH) with two different specific 
      probes for the regions containing 13q14 and 13q31 was used to delet the 
      chromosome in 21 patients with PCL. The results showed that 13 (61.9%) out of 21 
      PCL had 13q14 deletion. The number of 13q14 deletion cells ranged from 52% to 
      98%. 12 patients (57.4%) had 13q31 deletion. The number of cells with 13q31 
      deletion ranged from 50% to 98%. Out of 13 cases with (13q14) deletion, 12 cases 
      had (13q31) deletion, but only 1 out of 12 cases was negative. It is concluded 
      that chromosome 13 deletion may be involved in initiation of a subset of PCL, and 
      the region of loss at chromosome 13 locates between 13q14 and 13q31 in PCL. FISH 
      is a more rapid, exact and sensitive technique in analysis of chromosome 13 
      deletion in PCL.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, Jiangsu Province, China.
FAU - Li, Jian-Yong
AU  - Li JY
FAU - Fan, Lei
AU  - Fan L
FAU - Chen, Li-Juan
AU  - Chen LJ
FAU - Qiu, Hai-Rong
AU  - Qiu HR
FAU - Wang, Rong
AU  - Wang R
FAU - Qiao, Chun
AU  - Qiao C
FAU - Lu, Hua
AU  - Lu H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 13
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Leukemia, Plasma Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - Sequence Deletion
EDAT- 2008/12/23 09:00
MHDA- 2011/07/09 06:00
CRDT- 2008/12/23 09:00
PHST- 2008/12/23 09:00 [entrez]
PHST- 2008/12/23 09:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - 1009-2137(2008)06-1261-04 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1261-4.