PMID- 19100507
OWN - NLM
STAT- MEDLINE
DCOM- 20090114
LR  - 20101118
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 188
IP  - 2
DP  - 2009 Jan 15
TI  - Prognostic impact of chromosome alterations detected by FISH in Turkish patients 
      with B-cell chronic lymphocytic leukemia.
PG  - 65-9
LID - 10.1016/j.cancergencyto.2008.08.019 [doi]
AB  - The goal of this study was to evaluate the relation of chromosomal abnormalities 
      detected by fluorescence in situ hybridization (FISH) in the prognosis of B-cell 
      chronic lymphocytic leukemia (B-CLL) patients. We evaluated the common recurrent 
      chromosomal aberrations in 79 B-CLL patients (51 men, 28 women; mean age 
      64.3+/-1.2) by FISH analysis using 11q22.3 (ATM), 13q14.3 (13S319 and 13S25), 
      CEP12, and 17p13.1 (TP53) specific probes. Of the 79 patients analyzed by FISH, 
      40 or 50.6% had at least one aberration. In particular, 34 (43%) patients had a 
      single abnormality and 6 (7.6%) patients had 2 abnormalities. The most frequent 
      abnormality was 13q14.3 deletion, which was detected in 26 (32.9%) patients. 
      Trisomy 12 was seen in 12 (15.2%) cases, and was followed by 17p13.1 (TP53) 
      deletions and 11q22.3 (ATM) deletions in 6 (7.6%) and 4 (5.1%) patients, 
      respectively. When the overall frequencies of these chromosomal aberrations were 
      distributed according to RAI stages, the majority of patients with 13q14.3 
      deletion (55%), trisomy 12 (70%), and ATM or TP53 deletions (66.7 %) were in 
      advanced stages of disease (RAI II-IV). The overall survival durations in good, 
      intermediate, and poor prognostic groups were 51+/-1.3, 50.9+/-8.6, and 12+/-3.3 
      months, respectively. Our data suggests that FISH analysis of B-CLL patients 
      provides important diagnostic, clinical, and prognostic information which may 
      help clinicians assess the prognosis and make appropriate treatment decisions.
FAU - Durak, Beyhan
AU  - Durak B
AD  - Eskisehir Osmangazi University Medical Faculty Department of Medical Genetics, 
      Eskisehir, Turkey.
FAU - Akay, O Meltem
AU  - Akay OM
FAU - Aslan, Vahap
AU  - Aslan V
FAU - Ozdemir, Muhsin
AU  - Ozdemir M
FAU - Sahin, Fezan
AU  - Sahin F
FAU - Artan, Sevilhan
AU  - Artan S
FAU - Gulbas, Zafer
AU  - Gulbas Z
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 13
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Kaplan-Meier Estimate
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis/*genetics/mortality
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
MH  - Trisomy
MH  - Turkey
EDAT- 2008/12/23 09:00
MHDA- 2009/01/15 09:00
CRDT- 2008/12/23 09:00
PHST- 2008/06/09 00:00 [received]
PHST- 2008/08/05 00:00 [accepted]
PHST- 2008/12/23 09:00 [entrez]
PHST- 2008/12/23 09:00 [pubmed]
PHST- 2009/01/15 09:00 [medline]
AID - S0165-4608(08)00545-1 [pii]
AID - 10.1016/j.cancergencyto.2008.08.019 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2009 Jan 15;188(2):65-9. doi: 
      10.1016/j.cancergencyto.2008.08.019.