PMID- 19100537
OWN - NLM
STAT- MEDLINE
DCOM- 20100316
LR  - 20220311
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 93
IP  - 3
DP  - 2010 Feb
TI  - Human papillomavirus found in sperm head of young adult males affects the 
      progressive motility.
PG  - 802-6
LID - 10.1016/j.fertnstert.2008.10.050 [doi]
AB  - OBJECTIVE: To evaluate the prevalence of human papillomavirus (HPV) sperm 
      infection and its correlation with sperm parameters in a cohort of young adult 
      males. DESIGN: Cross-sectional clinical study. SETTING: Andrology and 
      Microbiology sections at a university hospital. PATIENT(S): A cohort of 200 young 
      adult male volunteers (18 years old), 100 with previous sexual intercourse and 
      100 without previous sexual intercourse. MAIN OUTCOME MEASURE(S): Seminal 
      parameters, sperm culture for HPV and fluorescence in situ hybridization (FISH) 
      analysis for HPV detection in the sperm head. Statistical analysis was performed 
      with a two-tailed Student's t-test. RESULT(S): Results of HPV investigation were 
      compared to sperm parameters and results of FISH analysis. HPV infection was 
      present in sperm cells of 10 subjects among those 100 young adults who already 
      had unprotected intercourse and its presence was associated with reduced sperm 
      motility. Furthermore, infected samples showed that about 25% of sperm had an HPV 
      DNA positivity at the head site, but it is unclear whether it was integrated in 
      the nucleus or not. CONCLUSION(S): This is the first report estimating the 
      percentage of HPV-positive sperm in infected subjects and the association between 
      HPV infection and sperm motility.
CI  - Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier 
      Inc. All rights reserved.
FAU - Foresta, Carlo
AU  - Foresta C
AD  - Department of Histology, Microbiology and Medical Biotechnologies, Section of 
      Clinical Pathology and Centre for Male Gamete Cryopreservation, University of 
      Padova, Italy. carlo.foresta@unipd.it
FAU - Garolla, Andrea
AU  - Garolla A
FAU - Zuccarello, Daniela
AU  - Zuccarello D
FAU - Pizzol, Damiano
AU  - Pizzol D
FAU - Moretti, Afra
AU  - Moretti A
FAU - Barzon, Luisa
AU  - Barzon L
FAU - Palu, Giorgio
AU  - Palu G
LA  - eng
PT  - Journal Article
DEP - 20081218
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adolescent
MH  - Asthenozoospermia/*virology
MH  - Coitus
MH  - Human papillomavirus 16/genetics/isolation & purification
MH  - Human papillomavirus 18/genetics/*isolation & purification
MH  - Human papillomavirus 6/genetics/isolation & purification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mass Screening/methods
MH  - Papillomavirus Infections/*diagnosis/virology
MH  - Sexually Transmitted Diseases, Viral/diagnosis/virology
MH  - Sperm Banks
MH  - Sperm Head/*virology
MH  - Sperm Motility/*physiology
EDAT- 2008/12/23 09:00
MHDA- 2010/03/17 06:00
CRDT- 2008/12/23 09:00
PHST- 2008/08/18 00:00 [received]
PHST- 2008/10/14 00:00 [revised]
PHST- 2008/10/16 00:00 [accepted]
PHST- 2008/12/23 09:00 [entrez]
PHST- 2008/12/23 09:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0015-0282(08)04408-7 [pii]
AID - 10.1016/j.fertnstert.2008.10.050 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Feb;93(3):802-6. doi: 10.1016/j.fertnstert.2008.10.050. Epub 
      2008 Dec 18.