PMID- 19101782
OWN - NLM
STAT- MEDLINE
DCOM- 20090617
LR  - 20211020
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 89
IP  - 1
DP  - 2009 Jan
TI  - Development of rapid light-chain deposition disease in hepatic arteries with 
      severe ischemic cholangitis in a multiple myeloma patient treated with melphalan, 
      prednisone and lenalidomide.
PG  - 91-94
LID - 10.1007/s12185-008-0228-7 [doi]
AB  - Light-chain deposition disease (LCDD) is a multisystemic disorder associated with 
      plasma cell dyscrasias and multiple myeloma. It is histologically characterized 
      by the deposition of a homogeneous, in electron microscopy granular, slightly 
      eosinophilic material showing positivity usually for kappa light chains. In 
      contrast to AL-amyloidosis, the material is negative for Congo red. LCDD mainly 
      involves the kidneys as the predominant organ manifestation resulting in a 
      nephrotic syndrome. However, involvement of other tissues such as liver and heart 
      have been described. Here we report a case of severe ischemic cholangitis in a 
      patient with multiple myeloma receiving chemotherapy with melphalan, prednisone, 
      and lenalidomide. Histopathological analysis revealed LCDD of the hepatic 
      arteries as the underlying cause. This is to our knowledge the first case of LCDD 
      of terminal liver arteries as a cause of intrahepatic ischemic cholangitis.
FAU - Weisel, Katja C
AU  - Weisel KC
AD  - Medical Center, Department of Hematology, Oncology and Immunology, University of 
      Tubingen, Otfried-Muller-Strasse 10, 72076, Tubingen, Germany. 
      katja.weisel@med.uni-tuebingen.de.
FAU - Bockeler, Michael
AU  - Bockeler M
AD  - Medical Center, Department of Hematology, Oncology and Immunology, University of 
      Tubingen, Otfried-Muller-Strasse 10, 72076, Tubingen, Germany.
FAU - Bianchi, Leonardo
AU  - Bianchi L
AD  - Institute for Pathology, Freiburg, Germany.
FAU - Terracciano, Luigi M
AU  - Terracciano LM
AD  - Institute for Pathology, Freiburg, Germany.
FAU - Mayer, Frank
AU  - Mayer F
AD  - Medical Center, Department of Hematology, Oncology and Immunology, University of 
      Tubingen, Otfried-Muller-Strasse 10, 72076, Tubingen, Germany.
FAU - Kanz, Lothar
AU  - Kanz L
AD  - Medical Center, Department of Hematology, Oncology and Immunology, University of 
      Tubingen, Otfried-Muller-Strasse 10, 72076, Tubingen, Germany.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20081220
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Immunoglobulin Light Chains)
RN  - 4Z8R6ORS6L (Thalidomide)
RN  - F0P408N6V4 (Lenalidomide)
RN  - Q41OR9510P (Melphalan)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*adverse effects
MH  - Cholangitis/chemically induced/*etiology/pathology
MH  - Hepatic Artery/*pathology
MH  - Humans
MH  - *Immunoglobulin Light Chains
MH  - Ischemia
MH  - Lenalidomide
MH  - Male
MH  - Melphalan/adverse effects
MH  - Multiple Myeloma/*complications/drug therapy
MH  - Paraproteinemias/complications
MH  - Prednisone/adverse effects
MH  - Thalidomide/adverse effects/analogs & derivatives
EDAT- 2008/12/23 09:00
MHDA- 2009/06/18 09:00
CRDT- 2008/12/23 09:00
PHST- 2008/08/07 00:00 [received]
PHST- 2008/11/10 00:00 [accepted]
PHST- 2008/10/21 00:00 [revised]
PHST- 2008/12/23 09:00 [entrez]
PHST- 2008/12/23 09:00 [pubmed]
PHST- 2009/06/18 09:00 [medline]
AID - 10.1007/s12185-008-0228-7 [pii]
AID - 10.1007/s12185-008-0228-7 [doi]
PST - ppublish
SO  - Int J Hematol. 2009 Jan;89(1):91-94. doi: 10.1007/s12185-008-0228-7. Epub 2008 
      Dec 20.