PMID- 19102353
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20131121
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 55
IP  - 86-87
DP  - 2008 Sep-Oct
TI  - Clinical characteristics of Helicobacter pylori-negative duodenal ulcer disease.
PG  - 1615-8
AB  - BACKGROUND/AIMS: Previous data on H. pylori-negative duodenal ulcer (DU) are 
      limited due to different exclusion criteria adopted. In this study we attempted 
      to clarify the characteristics of H. pylori-negative DU disease from patients 
      referred for endoscopy. METHODOLOGY: We recruited patients with DU disease and 
      without H. pylori infection as confirmed by biopsy urease and 13C-urea breath 
      tests. With each patient we carried out a structured personal interview including 
      basic demographic and clinical data, personal habits, use of NSAIDs/aspirin, 
      antibiotics, proton pump inhibitors (PPI) and anti-Hp therapy. If patients used 
      antibiotics or PPI, a urea breath test was performed four or two weeks after 
      discontinuation, respectively. RESULTS: The mean age of patients with H. 
      pylori-negative DU was 60.3 years (20-87). Among the 66 H. pylori-negative DU 
      patients, 34 (51.5%) had reported use of NSAID/aspirin, 24 (36.4%) had a history 
      of previous eradication therapy. Among the 32 non-H. pylori and non-NSAID DU 
      cases, five (15.6%) had psychophysical stress, four (12.6%) had co-morbid 
      illnesses, and two (6.3%) were alcoholics. CONCLUSIONS: NSAID/aspirin use is the 
      most common cause of H. pylori-negative DU disease. Psychophysical stress, 
      co-morbid illnesses, and alcohol abuse appear to be associated with the 
      development of non-H. pylori and non-NSAID DU disease.
FAU - Chen, Tseng-Shing
AU  - Chen TS
AD  - Division of Gastroenterology, Department of Medicine, Taipei Veterans General 
      Hospital, NO. 201, Sec. 2, Shih-Pai Road Taipei, Taiwan, 11217, R.O.C. 
      tschen@vghtpe.gov.tw
FAU - Chang, Full-Young
AU  - Chang FY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/adverse effects
MH  - Duodenal Ulcer/*etiology/microbiology
MH  - Ethanol/adverse effects
MH  - Female
MH  - Helicobacter pylori/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Smoking/adverse effects
MH  - Stress, Psychological/complications
EDAT- 2008/12/24 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/12/24 09:00
PHST- 2008/12/24 09:00 [entrez]
PHST- 2008/12/24 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1615-8.