PMID- 19102395
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20081223
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 55
IP  - 86-87
DP  - 2008 Sep-Oct
TI  - Survival benefit of pancreaticoduodenectomy in a Japanese fashion for a limited 
      group of patients with pancreatic head cancer.
PG  - 1789-95
AB  - BACKGROUND/AIMS: To evaluate the clinical benefit of pancreaticoduodenectomy in a 
      Japanese fashion for patients with pancreatic head cancer. METHODOLOGY: One 
      hundred and one patients underwent pancreatectomy for pancreatic head cancer 
      between 1980 and 2001. Of these, 40 patients in the extended resection (ER) group 
      had an extended lymphadenectomy and neural plexus dissection as a Japanese 
      fashion, while 61 patients in the conventional resection (CR) group. Tumor 
      status, morbidity, mortality, survival and pattern of recurrence were 
      retrospectively studied. RESULTS: The incidence of R0 operations in the ER group 
      was higher than that in the CR group (p<0.01). The actuarial 5-year survival rate 
      (30.6%) of patients with pStage IIA or IIB in the ER group was significantly 
      higher than that (8.2%) in the CR group (p=0.04) because local recurrence (47%) 
      in the CR group was higher than that (25%) in the ER group (p=0.02). In an 
      immunohistochemical study of isolated tumor cells (ITCs), 13 patients (57%) with 
      lymph node ITCs were included in the 23 pN0 patients. CONCLUSIONS: 
      Pancreaticoduodenectomy in a Japanese fashion with an adequate extended resection 
      might bring a survival benefit for patients with pStage IIA or IIB pancreatic 
      head cancer.
FAU - Takao, Sonshin
AU  - Takao S
AD  - Frontier Science Research Center, Kagoshima University, 8-35-1 Sakuragaoka, 
      Kagoshima 890-8520, Japan. sonshin@m2.kufm.kagoshima-u.ac.jp
FAU - Shinchi, Hiroyuki
AU  - Shinchi H
FAU - Maemura, Kosei
AU  - Maemura K
FAU - Kurahara, Hiroshi
AU  - Kurahara H
FAU - Natsugoe, Shoji
AU  - Natsugoe S
FAU - Aikou, Takashi
AU  - Aikou T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Pancreatic Neoplasms/mortality/pathology/*surgery
MH  - *Pancreaticoduodenectomy
EDAT- 2008/12/24 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/12/24 09:00
PHST- 2008/12/24 09:00 [entrez]
PHST- 2008/12/24 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1789-95.