PMID- 19106459
OWN - NLM
STAT- MEDLINE
DCOM- 20090421
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 73
IP  - 2
DP  - 2009 Feb
TI  - Impact of obstructive sleep apnea on the atrial electromechanical activation 
      time.
PG  - 249-55
AB  - BACKGROUND: Obstructive sleep apnea (OSA) is closely associated with atrial 
      fibrillation, which is provoked by electrical and structural remodeling. However, 
      the association between OSA and atrial remodeling has not been fully elucidated. 
      METHODS AND RESULTS: Atrial electromechanical activation time (EMAT) was 
      investigated using tissue Doppler imaging (TDI) in men with severe OSA (n=24) and 
      control subjects (n=24). The EMAT was determined as the time interval from the 
      initiation of P-wave deflection until the peak of local lateral left atrial (LA) 
      TDI signal. The early diastolic velocity of the mitral annulus (E(a)) and the 
      EMAT were significantly lower and longer in OSA cases than in controls (E(a): 
      6.1+/-0.9 cm/s vs 7.3+/-1.5 cm/s, P=0.001; EMAT: 129.7+/-11.5 ms vs 118.5+/-12.3 
      ms, P=0.002). Among OSA cases, the apnea - hypopnea index (AHI) was significantly 
      correlated with EMAT (r=0.660, P<0.001), E(a) (r=-0.609, P=0.002), LA dimension 
      (r=0.486, P=0.016), and early diastolic velocity of mitral flow (E)/E(a) ratio 
      (r=0.418, P=0.042). In multivariate stepwise linear regression analysis, EMAT was 
      independently associated with AHI (P=0.025) and E(a) (P=0.028) in OSA cases. 
      CONCLUSION: EMAT measured by TDI could be a useful parameter for identifying 
      atrial remodeling in patients with severe OSA.
FAU - Lim, Hong Euy
AU  - Lim HE
AD  - Division of Cardiology, Cardiovascular Center, College of Natural Science, 
      Kookmin University, Seoul, Korea.
FAU - Kim, Yong Hyun
AU  - Kim YH
FAU - Kim, Seong Hwan
AU  - Kim SH
FAU - Kim, Eung Ju
AU  - Kim EJ
FAU - Pak, Hui-Nam
AU  - Pak HN
FAU - Kim, Young-Hoon
AU  - Kim YH
FAU - Baik, Inkyung
AU  - Baik I
FAU - Shin, Chol
AU  - Shin C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081224
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/physiology
MH  - Case-Control Studies
MH  - Echocardiography
MH  - Heart Atria/diagnostic imaging/*physiopathology
MH  - Heart Conduction System/*physiopathology
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Polysomnography
MH  - Sleep Apnea, Obstructive/*physiopathology
EDAT- 2008/12/25 09:00
MHDA- 2009/04/22 09:00
CRDT- 2008/12/25 09:00
PHST- 2008/12/25 09:00 [entrez]
PHST- 2008/12/25 09:00 [pubmed]
PHST- 2009/04/22 09:00 [medline]
AID - JST.JSTAGE/circj/CJ-08-0813 [pii]
AID - 10.1253/circj.cj-08-0813 [doi]
PST - ppublish
SO  - Circ J. 2009 Feb;73(2):249-55. doi: 10.1253/circj.cj-08-0813. Epub 2008 Dec 24.