PMID- 19106523
OWN - NLM
STAT- MEDLINE
DCOM- 20090122
LR  - 20181201
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 35
IP  - 12
DP  - 2008 Nov
TI  - [A case of unresectable advanced gastric cancer successfully treated with 
      continuous S-1 + CPT-11 chemotherapy accompanied by dose reduction against grade 
      4 hematological adverse event].
PG  - 2060-2
AB  - We report a successful case of chemotherapy accompanied with grade 4 adverse 
      events for unresectable advanced gastric cancer. A 73-year-old man was admitted 
      to our hospital with complaint of abdominal pain in July 2007. The detailed 
      examination had revealed advanced gastric cancer, lymph node metastasis, and 
      multiple hepatic metastases. Performance status (PS) was level 0, and oral intake 
      of medications was possible. Combined therapy with S-1 and CPT-11 (IRIS regimen) 
      was performed from August as the first-line therapy. As a consequence of first 
      course, grade 4 hematological adverse events (AEs) appeared and an urgent 
      hospitalization was required. With whole body supportive care against grade 3 
      non-hematological AEs, which were diarrhea, anorexia, and fatigue, G-CSF, the 
      broad-spectrum antibiotic were administered at the clean-room. After 1 course, 
      cyto-reductive change was confirmed at the primary lesion and hepatic metastases. 
      We continued the same regimen with dose reduction (S-1: 2 level dose down, 
      CPT-11: 10% dose down). Although the regression of hepatic metastases was seen, 
      we repeated the dose reduction of CPT-11 and the dose down level was reached to 
      40% for prolonged grade 2 neutropenia. After 6th courses, complete responses at 
      primary lesion, lymph node, and hepatic metastases were achieved. The patient has 
      received the same regimen of 9th course continuously as an outpatient, and CR has 
      been maintained.
FAU - Miyazaki, Yasuhiro
AU  - Miyazaki Y
AD  - Dept. of Surgery, Sakai Municipal Hospital.
FAU - Imamura, Hiroshi
AU  - Imamura H
FAU - Kishimoto, Tomono
AU  - Kishimoto T
FAU - Furukawa, Hiroshi
AU  - Furukawa H
FAU - Ota, Katsuya
AU  - Ota K
FAU - Tatsuta, Masayuki
AU  - Tatsuta M
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Drug Combinations)
RN  - 150863-82-4 (S 1 (combination))
RN  - 1548R74NSZ (Tegafur)
RN  - 5VT6420TIG (Oxonic Acid)
RN  - 7673326042 (Irinotecan)
RN  - XT3Z54Z28A (Camptothecin)
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*adverse effects/*therapeutic use
MH  - Biopsy
MH  - Blood Cell Count
MH  - Camptothecin/adverse effects/*analogs & derivatives/therapeutic use
MH  - Cell Proliferation/drug effects
MH  - Drug Combinations
MH  - Gastroscopy
MH  - Humans
MH  - Irinotecan
MH  - Liver Neoplasms/drug therapy/secondary
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neoplasm Staging
MH  - Oxonic Acid/*adverse effects/*therapeutic use
MH  - Stomach Neoplasms/*drug therapy/pathology/surgery
MH  - Tegafur/*adverse effects/*therapeutic use
EDAT- 2008/12/25 09:00
MHDA- 2009/01/23 09:00
CRDT- 2008/12/25 09:00
PHST- 2008/12/25 09:00 [entrez]
PHST- 2008/12/25 09:00 [pubmed]
PHST- 2009/01/23 09:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2008 Nov;35(12):2060-2.