PMID- 19107613
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20211020
IS  - 1860-1480 (Print)
IS  - 1860-1499 (Linking)
VI  - 41
IP  - 4
DP  - 2008 Dec
TI  - Chromophobe renal cell carcinoma: useful diagnostic application of imprint 
      cytology and fluorescence in situ hybridization of chromosomes 10 and 21 in two 
      cases of typical and eosinophilic variants.
PG  - 227-32
LID - 10.1007/s00795-008-0406-y [doi]
AB  - Chromophobe renal cell carcinoma (RCC) is subdivided into typical and 
      eosinophilic variants. We report such two cases with focus on imprint cytology 
      and fluorescence in situ hybridization (FISH). The first case is a 53-year-old 
      Japanese man and the second is a 76-year-old Japanese man. Histologically, the 
      diagnosis of typical and eosinophilic variants of chromophobe RCC was suspected. 
      In imprint cytology, irregularity of nuclear membrane, binucleation, perinuclear 
      halo, and thick cell border were observed. Immunohistochemically, neoplastic 
      cells of both tumors were positive for cytokeratin 7, E-cadherin, c-kit, and 
      CD10. In FISH study, both tumors revealed the monosomy of chromosomes 10 and 21. 
      Additionally, FISH study in eosinophilic variant of chromophobe RCC showed the 
      disomy of chromosomes 7 and 17. In conclusion, we suggest that the combination 
      study of imprint cytology and FISH of chromosomes 10 and 21 as well as routine 
      histology may contribute to the accurate diagnosis of chromophobe RCC.
FAU - Kuroda, Naoto
AU  - Kuroda N
AD  - Departments of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 
      Shin-honmachi, Kochi, 780-8562, Japan. kurochankochi@yahoo.co.jp
FAU - Katto, Kazunobu
AU  - Katto K
FAU - Yamaguchi, Tadanori
AU  - Yamaguchi T
FAU - Kawada, Takako
AU  - Kawada T
FAU - Imamura, Yoshiaki
AU  - Imamura Y
FAU - Hes, Ondrej
AU  - Hes O
FAU - Michal, Michal
AU  - Michal M
FAU - Shuin, Taro
AU  - Shuin T
FAU - Lee, Gang-Hong
AU  - Lee GH
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20081224
PL  - Japan
TA  - Med Mol Morphol
JT  - Medical molecular morphology
JID - 101239023
SB  - IM
MH  - Carcinoma, Renal Cell/classification/*diagnosis/*genetics/pathology
MH  - *Chromosomes, Human, Pair 10
MH  - Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 21
MH  - Chromosomes, Human, Pair 7
MH  - *Cytological Techniques
MH  - Eosinophils
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - Kidney Neoplasms/classification/*diagnosis/*genetics/pathology
MH  - Male
MH  - Middle Aged
EDAT- 2008/12/25 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/12/25 09:00
PHST- 2008/03/26 00:00 [received]
PHST- 2008/05/21 00:00 [accepted]
PHST- 2008/12/25 09:00 [entrez]
PHST- 2008/12/25 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
AID - 10.1007/s00795-008-0406-y [doi]
PST - ppublish
SO  - Med Mol Morphol. 2008 Dec;41(4):227-32. doi: 10.1007/s00795-008-0406-y. Epub 2008 
      Dec 24.