PMID- 19107751
OWN - NLM
STAT- MEDLINE
DCOM- 20090928
LR  - 20211020
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 30
IP  - 8
DP  - 2009 Aug
TI  - Extraction of situational meaning by integrating multiple meanings in a complex 
      environment: a functional MRI study.
PG  - 2676-88
LID - 10.1002/hbm.20699 [doi]
AB  - Humans extract behaviorally significant meaning from a situation by integrating 
      meanings from multiple components of a complex daily environment. To determine 
      the neural underpinnings of this ability, the authors performed functional 
      magnetic resonance imaging of healthy subjects while the latter viewed 
      naturalistic scenes of two people and an object, including a threatening 
      situation of a person being attacked by an offender with an object. The authors 
      used a two-factorial design: the object was either aversive or nonaversive, and 
      the offender's action was either directed to the person or elsewhere. This 
      allowed the authors to examine the neural response to object aversiveness and 
      person-directed intention separately. A task unrelated to threat was also used to 
      address incidental (i.e., subconscious or unintentional) detection. Assuming 
      individual differences in incidental threat detection, the authors used a 
      functional connectivity analysis using principal components analysis of 
      intersubject variability. The left lateral orbitofrontal cortex and medial 
      prefrontal cortex (MPFC) were specifically activated in response to a threatening 
      situation. The threat-related component of intersubject variability was extracted 
      from these data and showed a significant correlation with personality scores. 
      There was also a correlation between threat-related intersubject variability and 
      activation for object aversiveness in the left temporal pole and lateral 
      orbitofrontal cortex; person-directed intention in the left superior frontal 
      gyrus; threatening situations in the left MPFC; and independently for both 
      factors in the right MPFC. Results demonstrate independent processing of object 
      aversiveness and person-directed intention in the left temporal-orbitofrontal and 
      superior frontal networks, respectively, and their integration into situational 
      meaning in the MPFC.
CI  - (c) 2008 Wiley-Liss, Inc.
FAU - Sugiura, Motoaki
AU  - Sugiura M
AD  - Department of Functional Brain Imaging, Institute of Development, Aging and 
      Cancer, Tohoku University, Aoba-ku, Sendai, Japan. motoaki@idac.tohoku.ac.jp
FAU - Wakusawa, Keisuke
AU  - Wakusawa K
FAU - Sekiguchi, Atsushi
AU  - Sekiguchi A
FAU - Sassa, Yuko
AU  - Sassa Y
FAU - Jeong, Hyeonjeong
AU  - Jeong H
FAU - Horie, Kaoru
AU  - Horie K
FAU - Sato, Shigeru
AU  - Sato S
FAU - Kawashima, Ryuta
AU  - Kawashima R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adolescent
MH  - Analysis of Variance
MH  - Brain/*physiology
MH  - Brain Mapping
MH  - Cognition/*physiology
MH  - Environment
MH  - Female
MH  - Frontal Lobe/physiology
MH  - Humans
MH  - Interpersonal Relations
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Photic Stimulation
MH  - Reaction Time
MH  - Thinking/*physiology
MH  - Young Adult
PMC - PMC6870784
EDAT- 2008/12/25 09:00
MHDA- 2009/09/29 06:00
PMCR- 2008/12/23
CRDT- 2008/12/25 09:00
PHST- 2008/12/25 09:00 [entrez]
PHST- 2008/12/25 09:00 [pubmed]
PHST- 2009/09/29 06:00 [medline]
PHST- 2008/12/23 00:00 [pmc-release]
AID - HBM20699 [pii]
AID - 10.1002/hbm.20699 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2009 Aug;30(8):2676-88. doi: 10.1002/hbm.20699.