PMID- 19108017
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20240416
IS  - 0513-5796 (Print)
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Linking)
VI  - 49
IP  - 6
DP  - 2008 Dec 31
TI  - Prevalence of Foxp3 positive T regulatory cells is increased during progression 
      of cutaneous squamous tumors.
PG  - 942-8
LID - 10.3349/ymj.2008.49.6.942 [doi]
AB  - PURPOSE: Forkhead box p3 (Foxp3) positive T regulatory cells (Tregs) have a 
      functionally immunosuppressive property that prevents effector cells from acting 
      against self in autoimmune diseases or a tumor. It is known that Tregs may be 
      highly relevant in cancer progression. Dendritic cells (DCs) induce cutaneous 
      immune response, however several studies have suggested that DCs are involved in 
      immunosuppression. The aim of this study is to evaluate the prevalence of Tregs 
      and DCs infiltration in cutaneous premalignant and malignant squamous lesions. 
      MATERIALS AND METHODS: We evaluated Tregs and DCs in skin tissue samples obtained 
      from 83 patients with actinic keratosis, Bowen's disease or squamous cell 
      carcinoma by immunohistochemistry. RESULTS: The prevalence of Tregs and DCs was 
      significantly higher in squamous cell carcinoma and Bowen's disease than in 
      actinic keratosis. In addition, the number of DCs was closely correlated with the 
      prevalence of Tregs, and DCs were also located in direct proximity to Tregs. 
      CONCLUSION: Tregs is related to cutaneous squamous tumor progression.
FAU - Jang, Tae Jung
AU  - Jang TJ
AD  - Department of Pathology, Dongguk University College of Medicine, 707 
      Sukjang-dong, Kyongju, Kyongbuk 780-714, Korea. taejung@mail.dongguk.ac.kr
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
SB  - IM
MH  - Bowen's Disease/immunology/metabolism/pathology
MH  - Carcinoma, Squamous Cell/immunology/metabolism/pathology
MH  - Dendritic Cells/immunology/metabolism/pathology
MH  - Forkhead Transcription Factors/immunology/*metabolism
MH  - Humans
MH  - Immune Tolerance
MH  - Keratosis, Actinic/immunology/metabolism/pathology
MH  - Skin Neoplasms/*immunology/metabolism/pathology
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism/pathology
PMC - PMC2628022
EDAT- 2008/12/25 09:00
MHDA- 2009/03/04 09:00
PMCR- 2008/12/31
CRDT- 2008/12/25 09:00
PHST- 2008/12/25 09:00 [entrez]
PHST- 2008/12/25 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
PHST- 2008/12/31 00:00 [pmc-release]
AID - 200812942 [pii]
AID - 10.3349/ymj.2008.49.6.942 [doi]
PST - ppublish
SO  - Yonsei Med J. 2008 Dec 31;49(6):942-8. doi: 10.3349/ymj.2008.49.6.942.