PMID- 19108018
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20211020
IS  - 0513-5796 (Print)
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Linking)
VI  - 49
IP  - 6
DP  - 2008 Dec 31
TI  - DNA gains and losses of chromosome in laryngeal squamous cell carcinoma using 
      comparative genomic hybridization.
PG  - 949-54
LID - 10.3349/ymj.2008.49.6.949 [doi]
AB  - PURPOSE: A larynx squamous cell carcinoma (LSCC) is one of the most common forms 
      of cancer and may exhibit various complex karyotypes. MATERIALS AND METHODS: We 
      used comparative genomic hybridization (CGH) to analyze DNA gains and losses in 
      15 squamous cell carcinomas that consisted of 4 glottic, 10 supraglottic, and 1 
      transglottic localization samples. RESULTS: The majority of the chromosomal 
      alterations detected were gains: 3 samples of LSCCs revealed high level 
      amplification, while 6 samples displayed gains in various chromosomal regions 
      (17p, 3p, 4p, 5p, 6q, 8p, 9p, 14q, 18p and Xq). One sample was found to have 
      losses (chromosomes 15q and 22q) and 5 had normal CGH profiles. CONCLUSION: Many 
      of these gained regions (4p, 5p, 8p, 10q, 18q and Xq) were novel sites, which may 
      harbor oncogene(s) that potentially play an important role in squamous cell 
      tumorigenesis and progression at supraglottic localizations.
FAU - Keser, Ibrahim
AU  - Keser I
AD  - Department of Medical Genetics, School of Medicine, Akdeniz University, TR-07070, 
      Antalya, Turkey. keser@akdeniz.edu.tr
FAU - Toraman, Ahter D
AU  - Toraman AD
FAU - Ozbilim, Gulay
AU  - Ozbilim G
FAU - Guney, Kenan
AU  - Guney K
FAU - Luleci, Guven
AU  - Luleci G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics
MH  - *Chromosome Aberrations
MH  - Comparative Genomic Hybridization
MH  - DNA, Neoplasm/*genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Laryngeal Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
PMC - PMC2628016
EDAT- 2008/12/25 09:00
MHDA- 2009/03/04 09:00
PMCR- 2008/12/31
CRDT- 2008/12/25 09:00
PHST- 2008/12/25 09:00 [entrez]
PHST- 2008/12/25 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
PHST- 2008/12/31 00:00 [pmc-release]
AID - 200812949 [pii]
AID - 10.3349/ymj.2008.49.6.949 [doi]
PST - ppublish
SO  - Yonsei Med J. 2008 Dec 31;49(6):949-54. doi: 10.3349/ymj.2008.49.6.949.