PMID- 19108814
OWN - NLM
STAT- MEDLINE
DCOM- 20090226
LR  - 20200928
IS  - 1550-8579 (Print)
IS  - 1550-8579 (Linking)
VI  - 5
IP  - 4
DP  - 2008 Dec
TI  - Gender- and age-related outcomes of cardiac resynchronization therapy: a pilot 
      observational study.
PG  - 415-22
LID - 10.1016/j.genm.2008.10.005 [doi]
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) has been reported to improve 
      clinical status and survival, and shorten hospitalization rates, in patients with 
      heart failure (HF). However, questions remain regarding the success of CRT in 
      different subgroups of patients with HE. OBJECTIVE: We assessed whether CRT 
      response was related to gender or age in patients with HE. METHODS: In a 
      longitudinal observational study, patients with severe HF (New York Heart 
      Association [NYHA] class III or IV, left ventricular ejection fraction [LVEF] 
      <or=35%, and QRS duration >120 ms with left bundle branch block configuration) 
      were enrolled. Clinical electrophysiologic and echocardiographic evaluations were 
      performed before, and 3 and 6 months after, CRT implantation. RESULTS: A total of 
      65 Iranian patients (50 men, 15 women; mean [SD] age, 60.3 [10.3] years; baseline 
      NYHA class, 3.1 [0.36]; QRS duration, 144 [14] ms; LVEF, 21% [7.3%]; left 
      ventricular end-diastolic diameter (LVEDD), 6.8 [0.56] mm) were evaluated. NYHA 
      class, QRS duration, LVEF, and LVEDD were significantly improved at 3- and 
      6-month follow-ups both in patients aged <or=60 years and in those aged >60 years 
      (P < 0.001, except for aged <or=60 years after 3-month follow-up [P = 0.002]). 
      All these parameters were significantly improved in men at 3- and 6-month 
      follow-ups (P < 0.001). NYHA class (P = 0.002), QRS duration (P = 0.001), LVEF (P 
      = 0.013 at 3 months and <0.001 at 6 months), and LVEDD (P = 0.007 at 3 months and 
      <0.001 at 6 months) also were significantly improved in women. At 3- and 6-month 
      follow-ups, there were no significant differences in improvement of these factors 
      between the 2 age groups of patients. CONCLUSION: CRT response in these patients 
      with HF did not appear to be gender or age related at 3- and 6-month follow-ups 
      in this small observational study. Confirmation of these findings by larger 
      studies is needed.
FAU - Kelarijani, Ramezan Bakhshian
AU  - Kelarijani RB
AD  - Clinical Research Unit, Baqiyatallah University of Medical Sciences, Tehran, 
      Iran. parsi.bakhshian@gmail.com
FAU - Saleh, Davoud Kazemi
AU  - Saleh DK
FAU - Chalian, Majid
AU  - Chalian M
FAU - Kabir, Ali
AU  - Kabir A
FAU - Ahmadzad Asl, Massoud
AU  - Ahmadzad Asl M
FAU - Dadjoo, Yahya
AU  - Dadjoo Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Gend Med
JT  - Gender medicine
JID - 101225178
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Heart Failure/diagnosis/*therapy
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial/*statistics & numerical data
MH  - Pilot Projects
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Stroke Volume
MH  - Treatment Outcome
EDAT- 2008/12/26 09:00
MHDA- 2009/02/27 09:00
CRDT- 2008/12/26 09:00
PHST- 2008/07/01 00:00 [accepted]
PHST- 2008/12/26 09:00 [entrez]
PHST- 2008/12/26 09:00 [pubmed]
PHST- 2009/02/27 09:00 [medline]
AID - S1550-8579(08)00105-8 [pii]
AID - 10.1016/j.genm.2008.10.005 [doi]
PST - ppublish
SO  - Gend Med. 2008 Dec;5(4):415-22. doi: 10.1016/j.genm.2008.10.005.