PMID- 19108958
OWN - NLM
STAT- MEDLINE
DCOM- 20090521
LR  - 20211203
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 101
IP  - 1-2
DP  - 2009 Apr 1
TI  - Using hepatitis C virus and herpes simplex virus-2 to track HIV among injecting 
      drug users in New York City.
PG  - 88-91
LID - 10.1016/j.drugalcdep.2008.11.007 [doi]
AB  - OBJECTIVE: To explore the potential utility of hepatitis C virus (HCV) 
      seroprevalence as a biomarker for injection risk, and herpes simplex virus-2 
      (HSV-2) as a biomarker for sexual risk among injecting drug users (IDUs). We 
      examined the relationships between HCV and HIV and between HSV-2 and HIV among 
      injecting drug users in New York City relative to the large-scale implementation 
      of syringe exchange in the mid-1990s. METHODS: 397 injecting drug users were 
      recruited from a drug detoxification program in New York from 2005 to 2007. 
      Informed consent was obtained, a questionnaire covering demographics, drug use 
      and HIV risk was administered. Blood samples were tested for antibody to HIV, HCV 
      and HSV-2. RESULTS: Among all subjects, HIV prevalence was 17%, HCV prevalence 
      72% and HSV-2 prevalence 48%. Among IDUs who began injecting before 1995, HIV was 
      28%, HCV serostatus was strongly associated with HIV serostatus (AOR=8.96, 95% CI 
      1.16-69.04) and HSV-2 serostatus was not associated with HIV serostatus 
      (AOR=1.31, 95% CI 0.64-2.67). Among subjects who began injecting in 1995 or 
      later, HIV was 6%, HCV was not associated with HIV (AOR=1.04, 95% CI 0.27-4.08) 
      and HSV-2 serostatus was strongly related to HIV serostatus (AOR=10.71, 95% CI 
      1.18-97.57). CONCLUSIONS: HCV and HSV-2 HCV and HSV-2 may provide important new 
      tools for monitoring evolving HIV epidemics among IDUs. Reconsideration of the 
      current CDC hierarchical transmission risk classification system may also be 
      warranted.
FAU - Des Jarlais, Don C
AU  - Des Jarlais DC
AD  - Beth Israel Medical Center, NewYork, NY 10038, USA. dcdesjarla@aol.com
FAU - Arasteh, Kamyar
AU  - Arasteh K
FAU - McKnight, Courtney
AU  - McKnight C
FAU - Hagan, Holly
AU  - Hagan H
FAU - Perlman, David
AU  - Perlman D
FAU - Friedman, Samuel R
AU  - Friedman SR
LA  - eng
GR  - R01 DA003574/DA/NIDA NIH HHS/United States
GR  - R01 DA 03574/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081223
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
SB  - IM
MH  - Adult
MH  - Ethnicity
MH  - Female
MH  - HIV Infections/*epidemiology/etiology
MH  - HIV Seroprevalence
MH  - *Hepacivirus
MH  - Hepatitis C/*epidemiology/*virology
MH  - Herpes Genitalis/*epidemiology/*virology
MH  - *Herpesvirus 2, Human
MH  - Humans
MH  - Male
MH  - Needle-Exchange Programs
MH  - New York City/epidemiology
MH  - Risk Assessment
MH  - Sex Factors
MH  - Socioeconomic Factors
MH  - Substance Abuse, Intravenous/complications/*epidemiology
EDAT- 2008/12/26 09:00
MHDA- 2009/05/22 09:00
CRDT- 2008/12/26 09:00
PHST- 2008/06/12 00:00 [received]
PHST- 2008/09/22 00:00 [revised]
PHST- 2008/11/06 00:00 [accepted]
PHST- 2008/12/26 09:00 [entrez]
PHST- 2008/12/26 09:00 [pubmed]
PHST- 2009/05/22 09:00 [medline]
AID - S0376-8716(08)00392-X [pii]
AID - 10.1016/j.drugalcdep.2008.11.007 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2009 Apr 1;101(1-2):88-91. doi: 
      10.1016/j.drugalcdep.2008.11.007. Epub 2008 Dec 23.