PMID- 19110127
OWN - NLM
STAT- MEDLINE
DCOM- 20090130
LR  - 20191210
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 633
IP  - 1
DP  - 2009 Feb 2
TI  - Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet 
      and keli by high-performance liquid chromatography.
PG  - 136-48
LID - 10.1016/j.aca.2008.11.043 [doi]
AB  - The objective of this paper was to establish an efficient method for quality 
      control of Lidanpaishi (LDPS) tablet and keli, two famous traditional Chinese 
      medicines. A simple and reliable high-performance liquid chromatography (HPLC) 
      coupled with photodiode array detector (DAD) method was developed both for 
      fingerprint analysis (FA) and quantitative determination. In quantitative 
      analysis, linear regressions, limit of detection (LOD) and quantification (LOQ), 
      intra-day and inter-day precisions, recovery, repeatability and stability were 
      all tested and good results were obtained to simultaneously determine the 15 
      marker compounds, namely chlorogenic acid, rhaponticin, 6,7-dimethoxycoumarin, 
      naringin, hesperidin, neohesperidin, baicalin, wogonoside, baicalein, wogonin, 
      chrysin, honokiol, magnolol, emodin, and chrysophanol in the herbal drugs. In 
      fingerprint analysis, 34 peaks were selected as the characteristic peaks to 
      evaluate the similarities of different samples collected from different 
      pharmaceutical companies in China according to the State Food and Drug 
      Administration (SFDA) requirements, and two kinds of data, relative retention 
      time (RRT) and relative peak area (RPA) were used to identify the common peaks in 
      15 samples for investigation. Furthermore, hierarchical cluster analysis (HCA) 
      was also performed to evaluate the variation of the herbal drugs. The present 
      approach, i.e. HPLC coupled with multiple compounds determination (MCD) and FA is 
      a powerful and meaningful tool to comprehensively conduct the quality control of 
      traditional Chinese medicines.
FAU - Xu, Lina
AU  - Xu L
AD  - College of Pharmacy, Dalian Medical University, Dalian, China.
FAU - Han, Xu
AU  - Han X
FAU - Qi, Yan
AU  - Qi Y
FAU - Xu, Youwei
AU  - Xu Y
FAU - Yin, Lianhong
AU  - Yin L
FAU - Peng, Jinyong
AU  - Peng J
FAU - Liu, Kexin
AU  - Liu K
FAU - Sun, Changkai
AU  - Sun C
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081127
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Solvents)
SB  - IM
MH  - Calibration
MH  - Chemistry Techniques, Analytical/methods
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drugs, Chinese Herbal/*analysis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Solid Phase Extraction/methods
MH  - Solvents/chemistry
MH  - Time Factors
EDAT- 2008/12/27 09:00
MHDA- 2009/01/31 09:00
CRDT- 2008/12/27 09:00
PHST- 2008/09/15 00:00 [received]
PHST- 2008/11/17 00:00 [revised]
PHST- 2008/11/17 00:00 [accepted]
PHST- 2008/12/27 09:00 [entrez]
PHST- 2008/12/27 09:00 [pubmed]
PHST- 2009/01/31 09:00 [medline]
AID - S0003-2670(08)01942-9 [pii]
AID - 10.1016/j.aca.2008.11.043 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2009 Feb 2;633(1):136-48. doi: 10.1016/j.aca.2008.11.043. Epub 
      2008 Nov 27.