PMID- 191104
OWN - NLM
STAT- MEDLINE
DCOM- 19770520
LR  - 20070723
IS  - 0320-9725 (Print)
IS  - 0320-9725 (Linking)
VI  - 41
IP  - 12
DP  - 1976 Dec
TI  - [Biochemical characteristics determining the rates of tumour growth in the 
      organism].
PG  - 2150-6
AB  - Experimental data suggest that contrary to the findings obtained for normal and 
      regenerating liver of mouse, the greater part of hexokinase (HK) in 
      transplantable hepatomas is firmly bound to mitochondrial membranes. It is shown 
      that the ratio of the bound HK activity (HKbound) to that of total HK activity 
      (HKtotal) diminishes with a hepatoma growth. Malignization of hepatocytes also 
      leads to a sharp decrease in the cytochrome oxidase (CO) octivity. Though the 
      data obtained are well-correlated with the Warburg hypothesis, there is no direct 
      correlation between the malignancy of hepatomas evaluated by their growth rates, 
      and the biochemical parameters of the tumours studied. On the basis of 
      fundamental principles of Warburg's, it is proposed to evaluate energy metabolism 
      of hepatomas by the activity and subcellular distribution patterns of HK as well 
      as be the activity of CO, according to the expression: 
      [(HKtotal)2//HKbound-CO+HKbound-CO]. It is demonstrated that there exists a 
      certain linear dependence between the integral characteristics of hepatoma 
      energetics and their growth rates.
FAU - Gobeev, V N
AU  - Gobeev VN
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Biokhimicheskie kharakteristiki, orpedeliaiushchie skorost' rosta opukholei 
      organizme.
PL  - Russia (Federation)
TA  - Biokhimiia
JT  - Biokhimiia (Moscow, Russia)
JID - 0372667
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - *Carcinoma, Hepatocellular/enzymology
MH  - Electron Transport Complex IV/*metabolism
MH  - Energy Metabolism
MH  - Hexokinase/*metabolism
MH  - Liver/*enzymology
MH  - *Liver Neoplasms/enzymology
MH  - Liver Regeneration
MH  - Mice
MH  - Neoplasm Transplantation
MH  - Neoplasms, Experimental/enzymology
MH  - Protein Binding
EDAT- 1976/12/01 00:00
MHDA- 1976/12/01 00:01
CRDT- 1976/12/01 00:00
PHST- 1976/12/01 00:00 [pubmed]
PHST- 1976/12/01 00:01 [medline]
PHST- 1976/12/01 00:00 [entrez]
PST - ppublish
SO  - Biokhimiia. 1976 Dec;41(12):2150-6.