PMID- 19110759
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20151119
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 60
IP  - 12
DP  - 2008 Dec
TI  - [Case of anti P/Q type VGCC antibody positive small lung cell carcinoma that 
      occured with subacute cerebellar degeneration, Lambert-Eaton myasthenic syndrome, 
      and brainstem encephalitis].
PG  - 1470-4
AB  - A 62-year-old man was admitted to our hospital because of rapidly progressive 
      dysarthria, truncal ataxia, and gait disturbance. High titers of the ProGRP and 
      anti-P/Q-type VGCC antibody were detected in the serum. High accumulation of 
      [18F] was detected at the hilus of the left lung on [18F]-FDG-PET scan. A 
      high-frequency repetitive stimulation test of the median nerve yielded an 
      incremental response. On the basis of these findings, a diagnosis of 
      paraneoplastic cerebellar degeneration (PCD) and Lambert-Eaton myasthenic 
      syndrome (LEMS) associated with small cell lung carcinoma (SCLC) was diagnosed. 
      After intravenous immunoglobulin therapy (IVIg), methylprednisolone (m-PSL) pulse 
      therapy, and other multidisciplinary concurrent treatments, a partial regression 
      of the SCLC and a significant improvement in neurological symptoms were observed. 
      However, ataxia relapsed and brainstem encephalitis developed 6 months later. A 
      marginal improvement in neurological symptoms was observed with IVIg, m-PSL pulse 
      therapy, and intravenous cyclophosphamide pulse therapy (IVCY). SCLC also 
      recurred later. We hypothesized that VGCC of the brainstem was damaged by 
      anti-P/Q-type VGCC antibody.
FAU - Nagayama, Shigemi
AU  - Nagayama S
AD  - Division of Neurology, Yanagawa Rehabilitation Hospital, Japan.
FAU - Koike, Fumihiko
AU  - Koike F
FAU - Sakai, Tetsuo
AU  - Sakai T
FAU - Antoku, Yasunobu
AU  - Antoku Y
FAU - Yukitake, Motohiro
AU  - Yukitake M
FAU - Kuroda, Yasuo
AU  - Kuroda Y
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Calcium Channels, P-Type)
RN  - 0 (Calcium Channels, Q-Type)
RN  - 0 (Peptide Fragments)
RN  - 0 (Recombinant Proteins)
RN  - 0 (pro-gastrin-releasing peptide (31-98))
SB  - IM
MH  - Autoantibodies/*blood
MH  - Biomarkers, Tumor/*blood
MH  - *Brain Stem
MH  - Calcium Channels, P-Type/*immunology
MH  - Calcium Channels, Q-Type/*immunology
MH  - Combined Modality Therapy
MH  - Encephalitis/diagnosis/*etiology/therapy
MH  - Humans
MH  - Lambert-Eaton Myasthenic Syndrome/diagnosis/*etiology/therapy
MH  - Lung Neoplasms/*complications/diagnosis/immunology/therapy
MH  - Male
MH  - Middle Aged
MH  - Paraneoplastic Cerebellar Degeneration/diagnosis/*etiology/therapy
MH  - Peptide Fragments/blood
MH  - Positron-Emission Tomography
MH  - Recombinant Proteins/blood
MH  - Small Cell Lung Carcinoma/*complications/diagnosis/immunology/therapy
MH  - Treatment Outcome
EDAT- 2008/12/30 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/12/30 09:00
PHST- 2008/12/30 09:00 [entrez]
PHST- 2008/12/30 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PST - ppublish
SO  - Brain Nerve. 2008 Dec;60(12):1470-4.