PMID- 19112225
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20111117
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 20
IP  - 1
DP  - 2009 Jan
TI  - HLA class I and II antigens expression in patients with renal cell carcinoma.
PG  - 97-101
AB  - An optimal antitumoral immune response requires the activation of both CD8(+) and 
      CD4(+) T lymphocytes by the peptide antigen presentation via the human leukocyte 
      antigen (HLA) class I and class II molecules, respectively. The frequency of A1, 
      A26, DR11 alleles are significantly elevated and seem to be the predisposing 
      alleles in RCC, while HLA A29 and DQ1 are the protective alleles and are found 
      more frequently in the healthy group. To investigate the association between 
      renal cell carcinoma (RCC) and the host's immune system, we immunohistochemically 
      examined RCCs in 44 Turkish patients for the expression of class I and class II 
      antigens. We found a significantly higher frequency of the alleles HLA-A1 (p= 
      0.001), HLA-A26 (p=0.047) and HLA-DR11 (p= 0.03) in RCC patients compared to the 
      control group. The most frequent alleles in the control population were A29, DQ1 
      (p= 0.004 and 0.002 respectively). We observed no significant difference between 
      patients and controls in HLA-B and HLA-C allele frequency. We conclude that our 
      study found an association between HLA antigens and RCC in Turkish patients. We 
      found a significantly higher frequency of the alleles HLA-A1, HLA-A26 and 
      HLA-DR11in RCC patients compared to the control group. Larger studies are 
      required to confirm these results.
FAU - Ozgur, B Cem
AU  - Ozgur BC
AD  - Department of Urology, Turkey Yuksek Ihtisas Education and Training Hospital, 
      Ankara, Turkey. bcemozgur@hotmail.com
FAU - Gonenc, Faruk
AU  - Gonenc F
FAU - Yazicioglu, Ahmet H
AU  - Yazicioglu AH
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*26 antigen)
RN  - 0 (HLA-A1 Antigen)
RN  - 0 (HLA-A29 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR11 antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Carcinoma, Renal Cell/*immunology
MH  - Female
MH  - HLA-A Antigens/immunology
MH  - HLA-A1 Antigen/immunology
MH  - HLA-DR Antigens/immunology
MH  - HLA-DR Serological Subtypes
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Kidney Neoplasms/*immunology
MH  - Male
MH  - Middle Aged
MH  - Turkey
EDAT- 2008/12/30 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/12/30 09:00
PHST- 2008/12/30 09:00 [entrez]
PHST- 2008/12/30 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2009 Jan;20(1):97-101.