PMID- 19114909
OWN - NLM
STAT- MEDLINE
DCOM- 20090506
LR  - 20220408
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 37
IP  - 2
DP  - 2009 Feb
TI  - Furosemide does not improve renal recovery after hemofiltration for acute renal 
      failure in critically ill patients: a double blind randomized controlled trial.
PG  - 533-8
LID - 10.1097/CCM.0b013e318195424d [doi]
AB  - OBJECTIVE: To study the potential beneficial role of furosemide in resolving 
      renal failure after hemofiltration in mechanically ventilated critically ill 
      patients. DESIGN: Single-center randomized, double blind, placebo-controlled 
      study. SETTING: A 13-bed mixed intensive care unit (ICU) in a teaching hospital. 
      PATIENTS: Patients who had been treated with continuous venovenous hemofiltration 
      were included. INTERVENTIONS: After the end of continuous venovenous 
      hemofiltration, the urine of the first 4 hours was collected for measuring 
      creatinine clearance. Patients were subsequently randomized for furosemide (0.5 
      mg/kg/hr) or placebo by continuous infusion. To prevent hypovolemia, the rate of 
      fluid infusion was adapted every hour and was set as the urinary production of 
      the previous hour. MEASUREMENTS AND MAIN RESULTS: End points were renal recovery 
      (creatinine clearance more than 30 mL/min or stable serum creatinine without 
      renal replacement therapy) in the ICU and in the hospital. Seventy-two patients 
      were included and 71 were eligible for the analysis. The 36 furosemide-treated 
      patients had a significantly increased urinary volume compared with the 35 
      placebo-treated patients (median 247 mL/hr (interquartile range [IQR] 774 mL/hr) 
      vs. 117 mL/hr (IQR 158 mL/hr), p = 0.003) and greater sodium excretion (median 73 
      mmol/L (IQR 48) vs. 37 (IQR 48) mmol/L, p = 0.001). In the furosemide group 25 
      patients and in the placebo group 27 patients showed recovery of renal function 
      at ICU discharge (p = 0.46). Two patients of the furosemide group needed 
      long-term dialysis dependency (p = 0.23). CONCLUSION: Furosemide by continuous 
      infusion in the recovery phase of hemofiltration-dependent acute kidney failure 
      did increase urinary volume and sodium excretion but did not lead to a shorter 
      duration of renal failure or more frequent renal recovery.
FAU - van der Voort, Peter H J
AU  - van der Voort PH
AD  - Department of Intensive Care, Onze Lieve Vrouwe Gasthuis, Amsterdam, The 
      Netherlands.
FAU - Boerma, E Christiaan
AU  - Boerma EC
FAU - Koopmans, Matty
AU  - Koopmans M
FAU - Zandberg, Mariet
AU  - Zandberg M
FAU - de Ruiter, Joke
AU  - de Ruiter J
FAU - Gerritsen, Rik T
AU  - Gerritsen RT
FAU - Egbers, Peter H M
AU  - Egbers PH
FAU - Kingma, W Peter
AU  - Kingma WP
FAU - Kuiper, Michael A
AU  - Kuiper MA
LA  - eng
SI  - ClinicalTrials.gov/NCT00298454
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
RN  - 0 (Diuretics)
RN  - 0 (Placebos)
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
CIN - Crit Care Med. 2009 Feb;37(2):761-2. PMID: 19325376
MH  - Acute Kidney Injury/*drug therapy
MH  - Aged
MH  - Aged, 80 and over
MH  - Critical Care
MH  - Diuretics/administration & dosage/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Furosemide/administration & dosage/*therapeutic use
MH  - *Hemofiltration
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - *Outcome Assessment, Health Care
MH  - Placebos
MH  - Respiration, Artificial
MH  - Severity of Illness Index
EDAT- 2008/12/31 09:00
MHDA- 2009/05/07 09:00
CRDT- 2008/12/31 09:00
PHST- 2008/12/31 09:00 [entrez]
PHST- 2008/12/31 09:00 [pubmed]
PHST- 2009/05/07 09:00 [medline]
AID - 10.1097/CCM.0b013e318195424d [doi]
PST - ppublish
SO  - Crit Care Med. 2009 Feb;37(2):533-8. doi: 10.1097/CCM.0b013e318195424d.