PMID- 19115127
OWN - NLM
STAT- MEDLINE
DCOM- 20090715
LR  - 20211020
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 15
IP  - 2
DP  - 2009 Apr
TI  - Bovine herpesvirus type 1 (BoHV-1) anterograde neuronal transport from trigeminal 
      ganglia to nose and eye requires glycoprotein E.
PG  - 196-201
LID - 10.1080/13550280802549605 [doi]
AB  - The requirement of bovine herpesvirus type 1 (BoHV-1) envelope protein gE (Us8 
      homolog) for establishment of latency and reactivation in trigeminal ganglia (TG) 
      was examined. Although BHV-1 gE-rescued and gE-deleted viruses were isolated from 
      nasal or ocular swabs during primary infection, only the gE-rescued virus was 
      isolated following dexamethasone-induced reactivation. Furthermore, gC protein 
      expression, which requires viral DNA replication for its expression, was detected 
      in TG of calves infected with either virus following reactivation. These studies 
      suggest that gE is required for anterograde transport of BoHV-1 from neuronal 
      cell bodies in the TG to their nerve processes.
FAU - Brum, Mario C S
AU  - Brum MC
AD  - Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 
      Kansas State University, Manhattan, Kansas, USA.
FAU - Coats, Charles
AU  - Coats C
FAU - Sangena, Rajkumari B
AU  - Sangena RB
FAU - Doster, Allan
AU  - Doster A
FAU - Jones, Clinton
AU  - Jones C
FAU - Chowdhury, Shafiqul I
AU  - Chowdhury SI
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Glucocorticoids)
RN  - 0 (Viral Proteins)
RN  - 0 (bovine herpesvirus type-1 glycoproteins)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Cattle Diseases/metabolism/*virology
MH  - Dexamethasone/pharmacology
MH  - Eye/*virology
MH  - Glucocorticoids/pharmacology
MH  - Herpesviridae Infections/metabolism/*veterinary/virology
MH  - Herpesvirus 1, Bovine/drug effects/*metabolism
MH  - Neurons/virology
MH  - Nose/*virology
MH  - Trigeminal Ganglion/*virology
MH  - Viral Proteins/*metabolism
MH  - Virus Activation/drug effects
MH  - Virus Latency/drug effects
EDAT- 2008/12/31 09:00
MHDA- 2009/07/16 09:00
CRDT- 2008/12/31 09:00
PHST- 2008/12/31 09:00 [entrez]
PHST- 2008/12/31 09:00 [pubmed]
PHST- 2009/07/16 09:00 [medline]
AID - 907242978 [pii]
AID - 10.1080/13550280802549605 [doi]
PST - ppublish
SO  - J Neurovirol. 2009 Apr;15(2):196-201. doi: 10.1080/13550280802549605.