PMID- 19116235
OWN - NLM
STAT- MEDLINE
DCOM- 20090407
LR  - 20220331
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 94
IP  - 3
DP  - 2009 Mar
TI  - Risk factors associated with a low glomerular filtration rate in primary 
      aldosteronism.
PG  - 869-75
LID - 10.1210/jc.2008-1851 [doi]
AB  - CONTEXT: Primary aldosteronism (PA) is associated with vascular end organ damage. 
      OBJECTIVE: We evaluated the newly established German Conn's Registry for evidence 
      of renal impairment and compared the data with those from hypertensive subjects 
      of a population-based survey. DESIGN: We conducted a case-control study. PATIENTS 
      AND CONTROLS: A total of 408 patients with PA from the Conn's registry treated in 
      five German centers were matched for age, sex, and body mass index in a 1:1 ratio 
      with 408 hypertensive control subjects from the population-based F3 survey of the 
      Kooperative Gesundheitsforschung in the region of Augsburg (KORA). MAIN OUTCOME 
      MEASURES: We measured serum creatinine and calculated glomerular filtration rate 
      (GFR). RESULTS: The percentage of patients with a serum creatinine concentration 
      above the normal range of 1.25 mg/dl was higher in patients with PA than in 
      hypertensive controls (29 vs. 10%; P < 0.001). Regression analysis showed that 
      age, male sex, low potassium, and high aldosterone concentrations were 
      independent predictors of a lower GFR. Adrenalectomy reduced systolic blood 
      pressure from a mean of 160 to 144 mm Hg. In parallel, we observed an increase in 
      serum creatinine and a decrease of GFR from 71 to 64 ml/min (P < 0.001). A 
      similar trend was seen after spironolactone treatment. CONCLUSIONS: In a large 
      cohort of patients with PA, markers of disease activity such as plasma 
      aldosterone and serum potassium are independent predictors of a lower GFR. 
      Specific interventions, such as adrenalectomy or spironolactone treatment, are 
      associated with a further decline in GFR.
FAU - Reincke, Martin
AU  - Reincke M
AD  - Medizinische Klinik-Innenstadt, Ludwig-Maximilians-Universitat Munchen, 80336 
      Munchen, Germany. martin.reincke@med.uni-muenchen.de.
FAU - Rump, Lars Christian
AU  - Rump LC
FAU - Quinkler, Marcus
AU  - Quinkler M
FAU - Hahner, Stephanie
AU  - Hahner S
FAU - Diederich, Sven
AU  - Diederich S
FAU - Lorenz, Reinhard
AU  - Lorenz R
FAU - Seufert, Jochen
AU  - Seufert J
FAU - Schirpenbach, Caroline
AU  - Schirpenbach C
FAU - Beuschlein, Felix
AU  - Beuschlein F
FAU - Bidlingmaier, Martin
AU  - Bidlingmaier M
FAU - Meisinger, Christa
AU  - Meisinger C
FAU - Holle, Rolf
AU  - Holle R
FAU - Endres, Stephan
AU  - Endres S
CN  - Participants of German Conn's Registry
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081230
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Mineralocorticoids)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adrenalectomy
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Creatinine/blood
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Hyperaldosteronism/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Mineralocorticoids/antagonists & inhibitors
MH  - Risk Factors
EDAT- 2009/01/01 09:00
MHDA- 2009/04/08 09:00
CRDT- 2009/01/01 09:00
PHST- 2009/01/01 09:00 [entrez]
PHST- 2009/01/01 09:00 [pubmed]
PHST- 2009/04/08 09:00 [medline]
AID - jc.2008-1851 [pii]
AID - 10.1210/jc.2008-1851 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2009 Mar;94(3):869-75. doi: 10.1210/jc.2008-1851. Epub 
      2008 Dec 30.