PMID- 19118553
OWN - NLM
STAT- MEDLINE
DCOM- 20090415
LR  - 20090320
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 216
IP  - 2
DP  - 2009 Apr
TI  - Normal cortical excitability in Myoclonus-Dystonia--a TMS study.
PG  - 300-5
LID - 10.1016/j.expneurol.2008.12.001 [doi]
AB  - OBJECTIVE: The aim of the present study is to investigate cortical excitability 
      in patients with DYT 11 positive Myoclonus-Dystonia (M-D), using transcranial 
      magnetic stimulation (TMS). METHODS: Silent period, motor evoked potential (MEP) 
      recruitment curve, short interval intracortical inhibition (SICI), intracortical 
      facilitation (ICF) and short interval intracortical facilitation (SICF), with 
      short interstimulus intervals (ISIs) ranging from 1.2 to 3.2 ms, were studied in 
      15 DYT 11-positive M-D patients and their matched controls. In four patients and 
      matched controls peripheral double pulse electrical nerve stimulation was 
      performed. RESULTS: All TMS parameters of cortical excitability were normal 
      compared to healthy controls. In the SICF protocol we observed more variable and 
      polyphasic MEPs in M-D patients. Cross-covariance analysis of MEP area revealed a 
      significant correlation difference at ISI 2.2 and 2.8 ms. This increased 
      variability was not seen in other TMS protocols or with peripheral nerve 
      stimulation. CONCLUSIONS: In contrast with other types of dystonia, no changes in 
      cortical excitability were found in DYT 11 patients. Our findings suggest that 
      M-D is both clinically and pathophysiologically a separate entity from other 
      dystonic disorders. Polyphasic MEPs during the SICF protocol in M-D patients 
      could reflect central neuron membrane instability. Application of the SICF 
      protocol in other patient groups has to prove its value in movement disorders.
FAU - van der Salm, S M A
AU  - van der Salm SM
AD  - Department of Neurology and Clinical Neurophysiology of the Academic Medical 
      Center, University of Amsterdam, The Netherlands.
FAU - van Rootselaar, A F
AU  - van Rootselaar AF
FAU - Foncke, E M J
AU  - Foncke EM
FAU - Koelman, J H T M
AU  - Koelman JH
FAU - Bour, L J
AU  - Bour LJ
FAU - Bhatia, K P
AU  - Bhatia KP
FAU - Rothwell, J C
AU  - Rothwell JC
FAU - Tijssen, M A J
AU  - Tijssen MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081211
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cerebral Cortex/*physiopathology
MH  - Dystonic Disorders/complications/*physiopathology
MH  - Electric Stimulation/methods
MH  - Electromyography
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myoclonus/complications/*physiopathology
MH  - Neural Inhibition/physiology
MH  - Peripheral Nerves/physiopathology
MH  - Reaction Time
MH  - Statistics, Nonparametric
MH  - *Transcranial Magnetic Stimulation
MH  - Young Adult
EDAT- 2009/01/03 09:00
MHDA- 2009/04/16 09:00
CRDT- 2009/01/03 09:00
PHST- 2008/07/13 00:00 [received]
PHST- 2008/10/28 00:00 [revised]
PHST- 2008/12/03 00:00 [accepted]
PHST- 2009/01/03 09:00 [entrez]
PHST- 2009/01/03 09:00 [pubmed]
PHST- 2009/04/16 09:00 [medline]
AID - S0014-4886(08)00470-6 [pii]
AID - 10.1016/j.expneurol.2008.12.001 [doi]
PST - ppublish
SO  - Exp Neurol. 2009 Apr;216(2):300-5. doi: 10.1016/j.expneurol.2008.12.001. Epub 
      2008 Dec 11.