PMID- 19118604
OWN - NLM
STAT- MEDLINE
DCOM- 20090520
LR  - 20211020
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 158
IP  - 4
DP  - 2009 Feb 18
TI  - Neurotensin inversely modulates maternal aggression.
PG  - 1215-23
LID - 10.1016/j.neuroscience.2008.11.045 [doi]
AB  - Neurotensin (NT) is a versatile neuropeptide involved in analgesia, hypothermia, 
      and schizophrenia. Although NT is released from and acts upon brain regions 
      involved in social behaviors, it has not been linked to a social behavior. We 
      previously selected mice for high maternal aggression (maternal defense), an 
      important social behavior that protects offspring, and found significantly lower 
      NT expression in the CNS of highly protective females. Our current study directly 
      tested NT's role in maternal defense. Intracerebroventricular (i.c.v.) injections 
      of NT significantly impaired defense in terms of time aggressive and number of 
      attacks at all doses tested (0.05, 0.1, 1.0, and 3.0 microg). Other maternal 
      behaviors, including pup retrieval, were unaltered following NT injections (0.05 
      microg) relative to vehicle, suggesting specificity of NT action on defense. 
      Further, i.c.v. injections of the NT receptor 1 (NT1) antagonist, SR 48692 (30 
      microg), significantly elevated maternal aggression in terms of time aggressive 
      and attack number. To understand where NT may regulate aggression, we examined 
      Fos following injection of either 0.1 microg NT or vehicle. Thirteen of 26 brain 
      regions examined exhibited significant Fos increases with NT, including regions 
      expressing NT1 and previously implicated in maternal aggression, such as lateral 
      septum, bed nucleus of stria terminalis, paraventricular nucleus, and central 
      amygdala. Together, our results indicate that NT inversely regulates maternal 
      aggression and provide the first direct evidence that lowering of NT signaling 
      can be a mechanism for maternal aggression. To our knowledge, this is the first 
      study to directly link NT to a social behavior.
FAU - Gammie, S C
AU  - Gammie SC
AD  - Department of Zoology, University of Wisconsin, Madison, WI 53706, USA. 
      scgammie@wisc.edu
FAU - D'Anna, K L
AU  - D'Anna KL
FAU - Gerstein, H
AU  - Gerstein H
FAU - Stevenson, S A
AU  - Stevenson SA
LA  - eng
GR  - R01 MH066086/MH/NIMH NIH HHS/United States
GR  - R01 MH066086-04/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081207
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Oncogene Proteins v-fos)
RN  - 0 (Pyrazoles)
RN  - 0 (Quinolines)
RN  - 0 (Receptors, Neurotensin)
RN  - 146362-70-1 (SR 48692)
RN  - 39379-15-2 (Neurotensin)
SB  - IM
MH  - Aggression/*drug effects/physiology
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal
MH  - Central Nervous System/drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Injections, Intraventricular/methods
MH  - Male
MH  - Maternal Behavior/*drug effects/physiology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurotensin/*pharmacology
MH  - Oncogene Proteins v-fos/metabolism
MH  - Pyrazoles/pharmacology
MH  - Quinolines/pharmacology
MH  - Reaction Time/drug effects
MH  - Receptors, Neurotensin/antagonists & inhibitors
PMC - PMC2646793
MID - NIHMS83138
EDAT- 2009/01/03 09:00
MHDA- 2009/05/21 09:00
PMCR- 2010/02/18
CRDT- 2009/01/03 09:00
PHST- 2008/10/13 00:00 [received]
PHST- 2008/11/11 00:00 [revised]
PHST- 2008/11/26 00:00 [accepted]
PHST- 2009/01/03 09:00 [entrez]
PHST- 2009/01/03 09:00 [pubmed]
PHST- 2009/05/21 09:00 [medline]
PHST- 2010/02/18 00:00 [pmc-release]
AID - S0306-4522(08)01751-X [pii]
AID - 10.1016/j.neuroscience.2008.11.045 [doi]
PST - ppublish
SO  - Neuroscience. 2009 Feb 18;158(4):1215-23. doi: 
      10.1016/j.neuroscience.2008.11.045. Epub 2008 Dec 7.