PMID- 19118645
OWN - NLM
STAT- MEDLINE
DCOM- 20090504
LR  - 20191210
IS  - 1567-133X (Print)
IS  - 1567-133X (Linking)
VI  - 9
IP  - 3
DP  - 2009 Mar
TI  - VITO-2, a new SID domain protein, is expressed in the myogenic lineage during 
      early mouse embryonic development.
PG  - 129-37
LID - 10.1016/j.gep.2008.12.002 [doi]
AB  - MCAT elements and its cognate binding partners, the transcription enhancer 
      factors (TEFs) play important roles in the regulation of expression of several 
      muscle-specific genes. The biological effects of TEFs strongly depend on 
      different co-factors, which might act as co-activators or anti-repressors to 
      enable transcriptional activation of target genes by TEFs. Previously, we have 
      cloned and characterized VITO-1, which acts as a skeletal muscle-specific 
      transcriptional co-activator of TEFs. Here we describe the cloning and expression 
      profile of a related gene, VITO-2 (also termed Vgl-3), which shares a high 
      homology with VITO-1 in the SID domain responsible for interaction with TEFs. 
      During early embryonic and fetal development VITO-2 is mainly expressed in the 
      myogenic lineage with an onset of expression in the myotomes of somites VI at 
      E9.5 slightly later than VITO-1. At later developmental stages VITO-2 is 
      predominantly found in the nervous system. In adult mice VITO-2 was detected in 
      different tissues, including skeletal muscle, heart, kidney, liver and brain, 
      where it was found in cortical and cerebellar neurons as well as in Purkinje 
      cells. The expression of VITO-2 in the mesoderm was repressed by the notch/delta 
      pathway and activated by Myf-5 since Dll-1 mutant showed an aberrant expression 
      of VITO-2 but not VITO-1 in the tail bud and in the caudal neural tube at E10.5 
      while Myf-5 mutant mice lack expression of VITO-1 and VITO-2 in somites until 
      E10.5.
FAU - Mielcarek, Michal
AU  - Mielcarek M
AD  - Max-Planck-Institute for Heart and Lung Research, Department of Cardiac 
      Development and Remodelling, Parkstr. 1, D-61231 Bad Nauheim, Hessen, Germany.
FAU - Piotrowska, Izabela
AU  - Piotrowska I
FAU - Schneider, Andre
AU  - Schneider A
FAU - Gunther, Stefan
AU  - Gunther S
FAU - Braun, Thomas
AU  - Braun T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081211
PL  - Netherlands
TA  - Gene Expr Patterns
JT  - Gene expression patterns : GEP
JID - 101167473
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Dlk1 protein, mouse)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Muscle Proteins)
RN  - 0 (Myf5 protein, mouse)
RN  - 0 (Myogenic Regulatory Factor 5)
RN  - 0 (Transcription Factors)
RN  - 0 (VITO-2 protein, mouse)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain/metabolism
MH  - Branchial Region/metabolism
MH  - Calcium-Binding Proteins
MH  - Cerebral Cortex/metabolism
MH  - Ganglia, Spinal/embryology/metabolism
MH  - Gene Expression Profiling
MH  - Intercellular Signaling Peptides and Proteins/deficiency
MH  - Kidney/metabolism
MH  - Liver/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle Development/*genetics
MH  - *Muscle Proteins/biosynthesis/genetics
MH  - Muscle, Skeletal/embryology/metabolism
MH  - Myocardium/metabolism
MH  - Myogenic Regulatory Factor 5/deficiency
MH  - Neuroepithelial Cells/metabolism
MH  - Purkinje Cells/metabolism
MH  - Somites/metabolism
MH  - Transcription Factors/*biosynthesis/*genetics
EDAT- 2009/01/03 09:00
MHDA- 2009/05/05 09:00
CRDT- 2009/01/03 09:00
PHST- 2008/05/29 00:00 [received]
PHST- 2008/11/25 00:00 [revised]
PHST- 2008/12/03 00:00 [accepted]
PHST- 2009/01/03 09:00 [entrez]
PHST- 2009/01/03 09:00 [pubmed]
PHST- 2009/05/05 09:00 [medline]
AID - S1567-133X(08)00123-3 [pii]
AID - 10.1016/j.gep.2008.12.002 [doi]
PST - ppublish
SO  - Gene Expr Patterns. 2009 Mar;9(3):129-37. doi: 10.1016/j.gep.2008.12.002. Epub 
      2008 Dec 11.