PMID- 19120099
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20090105
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1148
DP  - 2008 Dec
TI  - Effects of acute and chronic stressors and CRF in rat and mouse tests for 
      depression.
PG  - 118-26
LID - 10.1196/annals.1410.022 [doi]
AB  - Depressive illness is frequently associated with life stress. 
      Corticotropin-releasing factor (CRF) is believed to be a key brain mediator of 
      behaviors associated with stress, and abnormalities in the function of CRF have 
      been associated with depression. Therefore, we have studied the effects of acute 
      and chronic footshock and restraint in tests used in rodents to assess 
      depression-like activity and antidepressant effects: the forced swim test in rats 
      and mice, and the tail suspension test in mice. We also tested the effect of 
      intracerebroventricular (icv) CRF administration. The results were complex. In 
      the forced swim test in rats, acute footshock and restraint reduced floating, 
      whereas chronic footshock increased floating as did icv CRF. However, chronic 
      restraint induced opposite effects, decreasing floating in the forced swim test. 
      The results from mice were significantly different. In the forced swim test, 
      acute footshock and restraint decreased floating, while chronic footshock 
      increased floating, and chronic restraint decreased floating as it did in rats. 
      However, icv CRF decreased floating. The results from the tail-suspension test 
      paralleled those from the forced swim test except that chronic footshock tended 
      to decrease the time spent immobile. Thus in rats, the behavioral effects of the 
      chronic footshock in the forced swim test could be explained by a desensitization 
      of the CRF systems, either decreased activation of CRF, or desensitization of its 
      receptors. However, such an effect cannot explain the responses to restraint, nor 
      the behavioral effects of chronic footshock and restraint in mice.
FAU - Dunn, Adrian J
AU  - Dunn AJ
AD  - Department of Pharmacology, Toxicology and Neuroscience, Louisiana State 
      University Health Sciences Center, Shreveport, Louisiana, USA. ajdunn@hawaii.edu
FAU - Swiergiel, Artur H
AU  - Swiergiel AH
LA  - eng
GR  - MH50947/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal/drug effects/physiology
MH  - *Corticotropin-Releasing Hormone/metabolism/pharmacology
MH  - Depression/*physiopathology
MH  - Disease Models, Animal
MH  - Humans
MH  - Mice
MH  - Motor Activity/drug effects/physiology
MH  - Rats
MH  - Restraint, Physical
MH  - *Stress, Psychological
EDAT- 2009/01/06 09:00
MHDA- 2009/01/24 09:00
CRDT- 2009/01/06 09:00
PHST- 2009/01/06 09:00 [entrez]
PHST- 2009/01/06 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
AID - NYAS1148022 [pii]
AID - 10.1196/annals.1410.022 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2008 Dec;1148:118-26. doi: 10.1196/annals.1410.022.