PMID- 19120496
OWN - NLM
STAT- MEDLINE
DCOM- 20090220
LR  - 20240416
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 126
IP  - 1
DP  - 2009 Jan
TI  - Review series on helminths, immune modulation and the hygiene hypothesis: 
      mechanisms underlying helminth modulation of dendritic cell function.
PG  - 28-34
LID - 10.1111/j.1365-2567.2008.03008.x [doi]
AB  - Dendritic cells (DCs) play a central role in activating CD4 T (T helper, Th) 
      cells. As a component of their response to pathogen-associated stimuli, DCs 
      produce cytokines and express surface molecules that provide important cues to 
      modulate the effector functions of responding Th cells. Much is known of how DCs 
      respond to, and influence immune response outcome to, bacterial and viral 
      pathogens. However, relatively little is understood about how DCs respond to 
      helminth parasites. This is an area of considerable interest since it impacts our 
      understanding of the initiation of Th2 responses, which are stereotypically 
      associated with helminth infections, and the regulation of allergic and 
      autoimmune pathologies which evidence suggests are less severe or absent in 
      individuals infected with helminths. This review attempts to summarize our 
      understanding of the effects of helminth products on dendritic cell biology.
FAU - Carvalho, Lucas
AU  - Carvalho L
AD  - Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, 
      USA. lucaspc@vet.upenn.edu
FAU - Sun, Jie
AU  - Sun J
FAU - Kane, Colleen
AU  - Kane C
FAU - Marshall, Fraser
AU  - Marshall F
FAU - Krawczyk, Connie
AU  - Krawczyk C
FAU - Pearce, Edward J
AU  - Pearce EJ
LA  - eng
GR  - R01 AI053825/AI/NIAID NIH HHS/United States
GR  - R01 AI053825-07/AI/NIAID NIH HHS/United States
GR  - AI53825/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antigens, Helminth)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antigens, Helminth/immunology
MH  - Dendritic Cells/*immunology
MH  - Helminthiasis/immunology
MH  - Helminths/*immunology
MH  - Host-Parasite Interactions/immunology
MH  - Humans
MH  - Hygiene
MH  - Mice
MH  - Th2 Cells/immunology
MH  - Toll-Like Receptors/immunology
PMC - PMC2632707
EDAT- 2009/01/06 09:00
MHDA- 2009/02/21 09:00
PMCR- 2010/01/01
CRDT- 2009/01/06 09:00
PHST- 2009/01/06 09:00 [entrez]
PHST- 2009/01/06 09:00 [pubmed]
PHST- 2009/02/21 09:00 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - IMM3008 [pii]
AID - 10.1111/j.1365-2567.2008.03008.x [doi]
PST - ppublish
SO  - Immunology. 2009 Jan;126(1):28-34. doi: 10.1111/j.1365-2567.2008.03008.x.