PMID- 19120905
OWN - NLM
STAT- MEDLINE
DCOM- 20090420
LR  - 20211203
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 23 Suppl 2
DP  - 2008 Dec
TI  - Proton pump inhibitors and recurrent bleeding in peptic ulcer disease.
PG  - S237-41
LID - 10.1111/j.1440-1746.2008.05557.x [doi]
AB  - Peptic ulcer disease (PUD) is one of the main lesions responsible for upper 
      gastrointestinal (GI) bleeding, as well as esophageal varices and Mallory-Weiss 
      tear. Helicobacter pylori and non-steroidal anti-inflammatory drugs 
      (NSAIDs)/aspirin are the major responsible causes. In cases of upper GI bleeding, 
      urgent endoscopy is performed after stabilization of vital signs. There are 
      several modalities for controlling bleeding in PUD, such as ethanol injection or 
      hypertonic saline with epinephrine. Recurrent bleeding occurs in 20% of patients 
      after endoscopic therapy. The combination of endoscopic intervention and a proton 
      pump inhibitor (PPI) is necessary to achieve hemostasis of active bleeding. It 
      has been reported that high-dose omeprazole (80 mg bolus injection, then 8 mg/h 
      continuous infusion for 72 h, then 40 mg/day orally for 1 week) can reduce 
      recurrent bleeding, the need for surgery and mortality from hemorrhagic shock in 
      patients with high-risk peptic ulcer bleeding, as compared with standard-dose 
      omeprazole. The metabolism of PPIs is dependent upon P450 2C19 genotypes and the 
      clinical usefulness of genotypic analysis remains to be determined.
FAU - Tajima, Akihiro
AU  - Tajima A
AD  - Department of Gastroenterology, Dokkyo Medical University, Koshigaya Hospital, 
      Koshigaya, Japan. atajima@dokkyomed.ac.jp
FAU - Koizumi, Kazuhito
AU  - Koizumi K
FAU - Suzuki, Kazuyoshi
AU  - Suzuki K
FAU - Higashi, Naoko
AU  - Higashi N
FAU - Takahashi, Morio
AU  - Takahashi M
FAU - Shimada, Tadahito
AU  - Shimada T
FAU - Terano, Akira
AU  - Terano A
FAU - Hiraishi, Hideyuki
AU  - Hiraishi H
FAU - Kuwayama, Hajime
AU  - Kuwayama H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Proton Pump Inhibitors)
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
SB  - IM
MH  - Aryl Hydrocarbon Hydroxylases/genetics/metabolism
MH  - Combined Modality Therapy
MH  - Cytochrome P-450 CYP2C19
MH  - Drug Administration Schedule
MH  - Duodenal Ulcer/complications/*drug therapy/ethnology
MH  - Genotype
MH  - Hemostasis, Endoscopic
MH  - Humans
MH  - Peptic Ulcer Hemorrhage/ethnology/etiology/*prevention & control
MH  - Proton Pump Inhibitors/*administration & dosage/pharmacokinetics
MH  - Racial Groups/genetics
MH  - Recurrence
MH  - Shock, Hemorrhagic/etiology/prevention & control
MH  - Stomach Ulcer/complications/*drug therapy/ethnology
MH  - Treatment Outcome
RF  - 44
EDAT- 2009/01/16 09:00
MHDA- 2009/04/21 09:00
CRDT- 2009/01/06 09:00
PHST- 2009/01/06 09:00 [entrez]
PHST- 2009/01/16 09:00 [pubmed]
PHST- 2009/04/21 09:00 [medline]
AID - JGH5557 [pii]
AID - 10.1111/j.1440-1746.2008.05557.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2008 Dec;23 Suppl 2:S237-41. doi: 
      10.1111/j.1440-1746.2008.05557.x.