PMID- 19121567
OWN - NLM
STAT- MEDLINE
DCOM- 20090601
LR  - 20220331
IS  - 1097-6795 (Electronic)
IS  - 0894-7317 (Linking)
VI  - 22
IP  - 2
DP  - 2009 Feb
TI  - Feasibility of prediction of myocardial viability with Doppler tissue imaging 
      following percutaneous coronary intervention for ST elevation anterior myocardial 
      infarction.
PG  - 183-9
LID - 10.1016/j.echo.2008.11.018 [doi]
AB  - BACKGROUND: In patients with acute ST elevation myocardial infarction (STEMI), it 
      is clinically important to determine the viability of akinetic segments soon 
      after acute reperfusion therapy. The purpose of this study was to determine 
      whether Doppler tissue imaging can predict myocardial viability in this clinical 
      setting. METHODS: Twenty-four consecutive patients with the first acute anterior 
      STEMI with akinetic apical segments were enrolled. Color-coded Doppler tissue 
      imaging was performed. Myocardial velocity and strain values were determined from 
      the septal and lateral walls at the normal basal and akinetic apical levels of 
      the left ventricle on day 1 after percutaneous coronary intervention. The 
      presence of isovolumic contraction of tissue velocity (TVivc) and strain rate 
      (SRivc) were also determined. RESULTS: Twenty patients (mean age 62 +/- 15 years; 
      11 men) returned for follow-up echocardiography to assess wall motion recovery 
      and viability. Ten patients who had recovery of akinetic segments showed lower 
      baseline E/e' ratios than those without recovery (13.4 +/- 5.9 vs 19.1 +/- 5.7; P 
      = .04). There was no difference between 19 recovered and 21 nonrecovered apical 
      segments in all TV, SR, and strain values except early diastolic SR (SRe; 0.64 
      +/- 0.35 vs 0.43 +/- 0.25 s(-1); P = .04) at day 1. With a cutoff value of 0.32 
      s(-1) for SRe, the receiver operating characteristic curve for the prediction of 
      recovery showed the highest sensitivity of 84%. The presence of TVivc had 
      sensitivity and specificity of 79% and 33%, respectively, and for SRivc, 
      sensitivity and specificity were 84% and 63%, respectively. With the combination 
      of SRe and SRivc, specificity was increased to 78%. CONCLUSION: Patients with 
      functional recovery from anterior STEMI showed better diastolic function, better 
      SRe, and more isovolumic contraction. These parameters appear to be promising 
      predictors for myocardial viability, and SR imaging was found to be a better 
      method than TV imaging for the identification of viable myocardium in patients 
      with STEMIs who underwent percutaneous coronary intervention.
FAU - Park, Seong-Mi
AU  - Park SM
AD  - Division of Cardiology, Korea University College of Medicine, Seoul, South Korea.
FAU - Miyazaki, Chinami
AU  - Miyazaki C
FAU - Prasad, Abhiram
AU  - Prasad A
FAU - Bruce, Charles J
AU  - Bruce CJ
FAU - Chandrasekaran, Krishnaswamy
AU  - Chandrasekaran K
FAU - Rihal, Charanjit
AU  - Rihal C
FAU - Bell, Malcolm R
AU  - Bell MR
FAU - Oh, Jae K
AU  - Oh JK
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20090101
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
SB  - IM
MH  - Angioplasty, Balloon, Coronary/*methods
MH  - Echocardiography, Doppler/*methods
MH  - Elasticity Imaging Techniques/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*diagnostic imaging/*surgery
MH  - Myocardial Stunning/*diagnostic imaging/etiology/*prevention & control
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
EDAT- 2009/01/06 09:00
MHDA- 2009/06/02 09:00
CRDT- 2009/01/06 09:00
PHST- 2008/01/26 00:00 [received]
PHST- 2009/01/06 09:00 [entrez]
PHST- 2009/01/06 09:00 [pubmed]
PHST- 2009/06/02 09:00 [medline]
AID - S0894-7317(08)00715-3 [pii]
AID - 10.1016/j.echo.2008.11.018 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2009 Feb;22(2):183-9. doi: 10.1016/j.echo.2008.11.018. 
      Epub 2009 Jan 1.