PMID- 19121816
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20211028
IS  - 1937-6448 (Print)
IS  - 1937-6448 (Linking)
VI  - 272
DP  - 2009
TI  - New insights into the roles of dendritic cells in intestinal immunity and 
      tolerance.
PG  - 33-105
LID - 10.1016/S1937-6448(08)01602-X [doi]
AB  - Dendritic cells (DCs) play a critical key role in the initiation of immune 
      responses to pathogens. Paradoxically, they also prevent potentially damaging 
      immune responses being directed against the multitude of harmless antigens, to 
      which the body is exposed daily. These roles are particularly important in the 
      intestine, where only a single layer of epithelial cells provides a barrier 
      against billions of commensal microorganisms, pathogens, and food antigens, over 
      a huge surface area. In the intestine, therefore, DCs are required to perform 
      their dual roles very efficiently to protect the body from the dual threats of 
      invading pathogens and unwanted inflammatory reactions. In this review, we first 
      describe the biology of DCs and their interactions with other cells types, paying 
      particular attention to intestinal DCs. We, then, examine the ways in which this 
      biology may become misdirected, resulting in inflammatory bowel disease. Finally, 
      we discuss how DCs potentiate immune responses against viral, bacterial, 
      parasitic infections, and their importance in the pathogenesis of prion diseases. 
      We, therefore, provide an overview of the complex cellular interactions that 
      affect intestinal DCs and control the balance between immunity and tolerance.
FAU - Cerovic, Vuk
AU  - Cerovic V
AD  - Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom.
FAU - McDonald, Victoria
AU  - McDonald V
FAU - Nassar, Mark A
AU  - Nassar MA
FAU - Paulin, Susan M
AU  - Paulin SM
FAU - Macpherson, G Gordon
AU  - Macpherson GG
FAU - Milling, Simon W F
AU  - Milling SW
LA  - eng
GR  - BB/D012643/2/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Int Rev Cell Mol Biol
JT  - International review of cell and molecular biology
JID - 101475846
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cell Movement/*physiology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - Inflammatory Bowel Diseases/*immunology/microbiology
MH  - Intestines/*cytology/immunology
MH  - Mucous Membrane/cytology/immunology
MH  - Parasitic Diseases/immunology
MH  - Virus Diseases/*immunology
RF  - 440
EDAT- 2009/01/06 09:00
MHDA- 2009/02/20 09:00
CRDT- 2009/01/06 09:00
PHST- 2009/01/06 09:00 [entrez]
PHST- 2009/01/06 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
AID - S1937-6448(08)01602-X [pii]
AID - 10.1016/S1937-6448(08)01602-X [doi]
PST - ppublish
SO  - Int Rev Cell Mol Biol. 2009;272:33-105. doi: 10.1016/S1937-6448(08)01602-X.